HLA-DR Antibody (Bra20): sc-33720

HLA-DR Antibody (Bra20) is a mouse monoclonal IgG2b kappa light chain antibody engineered to target the HLA-DR protein, also known as human leukocyte antigen DR or MHC class II DR. The HLA-DR protein is a critical component of the major histocompatibility complex (MHC) class II molecules, which are essential for presenting antigenic peptides to CD4+ T helper cells, thereby initiating and regulating immune responses. HLA-DR undergoes significant post-translational modifications, including glycosylation, which are crucial for its proper folding, stability, and expression on the cell surface, ensuring effective antigen presentation and immune system functionality. Anti-HLA-DR antibody (Bra20) is raised against the Reh-6 non-T, non-B leukemia cell line and demonstrates broad species reactivity, effectively recognizing HLA-DR from mouse, rat, and human origins. HLA-DR (Bra20) antibody is versatile in its applications, suitable for western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM), providing reliable and specific detection of HLA-DR across various experimental settings. By specifically binding to HLA-DR without cross-reacting with other MHC class II molecules, HLA-DR monoclonal antibody (Bra20) ensures precise targeting, which is essential for studies involving immune cell interactions, antigen presentation mechanisms, and the molecular basis of immune-related diseases such as autoimmune disorders and cancers. Additionally, understanding the post-translational modifications of HLA-DR facilitated by anti-HLA-DR antibody (Bra20) can lead to deeper insights into protein function and stability, advancing the development of targeted immunotherapies and diagnostic tools. Available in both conjugated and unconjugated forms, HLA-DR (Bra20) monoclonal antibody is an indispensable tool for researchers aiming to elucidate the complexities of immune regulation and enhance therapeutic strategies, ultimately contributing to improved patient outcomes and scientific advancements in immunology.

The preferred HLA-DR antibody is HLA-DR Antibody (L243): sc-18875.