HLA-DR Inhibitors
Common HLA-DR Inhibitors include, but are not limited to Ivermectin CAS 70288-86-7, Thalidomide CAS 50-35-1, Dexamethasone CAS 50-02-2, Rapamycin CAS 53123-88-9 and Cyclosporin A CAS 59865-13-3.
HLA-DR inhibitors belong to a distinct chemical class of compounds designed to modulate the activity of the HLA-DR protein. HLA-DR, short for Human Leukocyte Antigen-DR, is a pivotal member of the major histocompatibility complex (MHC) class II molecules, playing a crucial role in immune system responses by presenting antigens to immune cells. These inhibitors are carefully crafted molecules tailored to interact with the HLA-DR protein, affecting its normal functioning. Through these interactions, they might influence various cellular processes associated with antigen presentation and immune responses, without directly impacting its binding to specific antigens or its involvement in immune cell interactions.
The design of HLA-DR inhibitors is informed by a deep understanding of the structural and functional attributes of the HLA-DR protein. Advanced chemical synthesis methods and insights from structural biology are commonly employed in the development of these inhibitors. Their notable characteristic lies in their ability to selectively bind to HLA-DR, enabling focused modulation of cellular processes that rely on the participation of this specific MHC class II molecule. Researchers and scientists interested in unraveling the complexities of immune system functioning and antigen presentation often utilize HLA-DR inhibitors as valuable tools. Through systematic experimentation, they can investigate how the inhibition of HLA-DR influences various cellular processes, thereby contributing to a deeper understanding of its involvement in diverse immunological and cellular contexts. The development and utilization of HLA-DR inhibitors contribute to advancing our knowledge of the intricate interplay between immune components and functions, offering insights into the fundamental molecular mechanisms that underlie immune responses and antigen recognition.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $56.00 | 1 | |
Similar to chloroquine, this drug can also interfere with antigen presentation. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Affects protein transport in cells and may inhibit the presentation of antigens by HLA-D. | ||||||
Ivermectin | 70288-86-7 | sc-203609 sc-203609A | 100 mg 1 g | $56.00 $75.00 | 2 | |
Ivermectin downregulates HLA-DR expression by modulating immune responses. It inhibits cytokine production, leading to decreased MHC class II expression and subsequently impaired antigen presentation. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $72.00 $145.00 $265.00 $489.00 $1399.00 $99.00 | 19 | |
A protease inhibitor that can affect antigen processing, thereby impacting its presentation by HLA-D. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $109.00 $350.00 | 8 | |
Thalidomide inhibits HLA-DR expression by reducing the secretion of pro-inflammatory cytokines like TNF-alpha and IFN-gamma. This dampens immune responses and lowers MHC class II expression, thereby affecting antigen presentation. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that can interfere with antigen processing and presentation. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone is a corticosteroid that suppresses immune responses. It inhibits HLA-DR expression by blocking the transcription of MHC class II genes and dampening the immune system's activation and subsequent antigen presentation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits HLA-DR expression by targeting the mTOR pathway. It disrupts mTOR signaling, leading to downregulation of MHC class II expression and impairing the processing and presentation of antigens to T cells. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporine A inhibits HLA-DR expression by suppressing T cell activation. It hinders calcineurin activity and downstream NFAT signaling, thereby reducing the production of cytokines that drive MHC class II expression and antigen presentation. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $76.00 $148.00 | 9 | |
FK506 inhibits HLA-DR expression by blocking calcineurin and NFAT activation, similar to Cyclosporine A. It modulates T cell responses, dampening the production of cytokines necessary for MHC class II gene expression and antigen presentation. | ||||||