HERG Antibody (F-3): sc-515611

HERG Antibody (F-3) is a mouse monoclonal IgG2b antibody that detects Human ether-a-go-go related gene (HERG) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). HERG encodes the pore-forming α subunit of the delayed rectifier potassium channel IKr, which plays a crucial role in cardiac repolarization. HERG (F-3) antibody helps researchers study the flow of potassium ions across cell membranes during cardiac action potential. Disruptions in HERG function, often due to genetic mutations, can lead to serious cardiac conditions such as long QT syndrome, characterized by prolonged repolarization of the heart′s electrical cycle, which increases the risk of arrhythmias and sudden cardiac death. HERG protein is primarily located in cardiac myocytes of the ventricles, where expression is significantly higher than in the atria, underscoring HERG′s importance in ventricular function and overall cardiac health. Anti-HERG antibody (F-3) serves as an essential tool for researchers studying cardiac physiology and molecular mechanisms underlying arrhythmias, providing insights into potential therapeutic targets for heart disease.

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HERG Antibody (F-3) References:

1. Progesterone impairs human ether-a-go-go-related gene (HERG) trafficking by disruption of intracellular cholesterol homeostasis.  |  Wu, ZY., et al. 2011. J Biol Chem. 286: 22186-94. PMID: 21525004
2. Human Ether-à-go-go Related Gene (hERG) Channel Blocking Aporphine Alkaloids from Lotus Leaves and Their Quantitative Analysis in Dietary Weight Loss Supplements.  |  Grienke, U., et al. 2015. J Agric Food Chem. 63: 5634-9. PMID: 26035250
3. Rab11-dependent Recycling of the Human Ether-a-go-go-related Gene (hERG) Channel.  |  Chen, J., et al. 2015. J Biol Chem. 290: 21101-21113. PMID: 26152716
4. Regulation of the human ether-a-go-go-related gene (hERG) potassium channel by Nedd4 family interacting proteins (Ndfips).  |  Kang, Y., et al. 2015. Biochem J. 472: 71-82. PMID: 26363003
5. A temperature-dependent in silico model of the human ether-à-go-go-related (hERG) gene channel.  |  Li, Z., et al. 2016. J Pharmacol Toxicol Methods. 81: 233-9. PMID: 27178106
6. F463L increases the potential of dofetilide on human ether-a-go-go-related gene (hERG) channels.  |  Cheng, G., et al. 2018. Microsc Res Tech. 81: 663-668. PMID: 29573040
7. Trafficking of the human ether-a-go-go-related gene (hERG) potassium channel is regulated by the ubiquitin ligase rififylin (RFFL).  |  Roder, K., et al. 2019. J Biol Chem. 294: 351-360. PMID: 30401747
8. Differential Regulation of Human Ether-à-Go-Go-Related Gene (hERG) Current and Expression by Activation of Protein Kinase C.  |  Sutherland-Deveen, ME., et al. 2019. Mol Pharmacol. 96: 1-12. PMID: 31015282
9. Discovery of 2-vinyl-10H-phenothiazine derivatives as a class of ferroptosis inhibitors with minimal human Ether-a-go-go related gene (hERG) activity for the treatment of DOX-induced cardiomyopathy.  |  You, J., et al. 2022. Bioorg Med Chem Lett. 74: 128911. PMID: 35907606
10. Human ether-a-gogo related gene (HERG) K+ channels as pharmacological targets: present and future implications.  |  Taglialatela, M., et al. 1998. Biochem Pharmacol. 55: 1741-6. PMID: 9714291

The preferred HERG antibody is HERG Antibody (F-12): sc-377388.