Histone Deacetylase 1 (HDAC1) Antibody (10E2): sc-81598

HDAC1 Antibody (10E2) is a mouse monoclonal IgG1 kappa light chain antibody engineered to target Histone Deacetylase 1 (HDAC1) by recognizing the C-terminal epitope encompassing amino acids 467-482a of the human protein. Anti-HDAC1 antibody (10E2) exhibits robust species reactivity, effectively detecting HDAC1 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). HDAC1, also called GON-10, HD1, KDAC1, RPD3, and RPD3L1, is predominantly localized within the nucleus, where HDAC1 plays a crucial role in the regulation of gene expression by deacetylating histone proteins. This deacetylation leads to chromatin condensation and transcriptional repression, which are essential processes for maintaining genomic stability, controlling cell cycle progression, and facilitating cellular differentiation. The nuclear presence of HDAC1 is vital for modulating the accessibility of transcription factors to DNA, thereby influencing various cellular pathways and processes. Dysregulation of HDAC1 has been implicated in numerous diseases, including cancer, neurological disorders, and inflammatory conditions, making HDAC1 a significant target for therapeutic interventions and a key focus in epigenetic research. Available in both non-conjugated form and multiple conjugated variants such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates, HDAC1 (10E2) antibody provides versatile options to meet diverse experimental needs. Anti-HDAC1 antibody (10E2) serves as an indispensable tool for researchers exploring the intricate mechanisms of epigenetic regulation and its impact on cellular function and disease progression.

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Histone Deacetylase 1 (HDAC1) Antibody (10E2) References:

1. HDAC1 promotes the migration of human myeloma cells via regulation of the lncRNA/Slug axis.  |  Zheng, L., et al. 2022. Int J Mol Med. 49: PMID: 34738621
2. HDAC1 overexpression promoted by METTL3-IGF2BP2 inhibits FGF21 expression in metabolic syndrome-related liver injury.  |  Chen, Y., et al. 2023. Biochem Cell Biol. 101: 52-63. PMID: 36542845
3. HDAC1/2 and HDAC3 play distinct roles in controlling adult Meibomian gland homeostasis.  |  Zhu, X., et al. 2024. Ocul Surf. 33: 39-49. PMID: 38679196
4. The histone deacetylase HDAC1 controls dendritic cell development and anti-tumor immunity.  |  De Sá Fernandes, C., et al. 2024. Cell Rep. 43: 114308. PMID: 38829740
5. Nucleosome structural changes due to acetylation.  |  Bauer, WR., et al. 1994. J Mol Biol. 236: 685-90. PMID: 8114086
6. A positive role for histone acetylation in transcription factor access to nucleosomal DNA.  |  Lee, DY., et al. 1993. Cell. 72: 73-84. PMID: 8422685
7. Transcriptional silencing in yeast is associated with reduced nucleosome acetylation.  |  Braunstein, M., et al. 1993. Genes Dev. 7: 592-604. PMID: 8458576
8. Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation.  |  Brownell, JE., et al. 1996. Cell. 84: 843-51. PMID: 8601308
9. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p.  |  Taunton, J., et al. 1996. Science. 272: 408-11. PMID: 8602529
10. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A.  |  Yang, XJ., et al. 1996. Nature. 382: 319-24. PMID: 8684459
11. Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3.  |  Yang, WM., et al. 1996. Proc Natl Acad Sci U S A. 93: 12845-50. PMID: 8917507
12. Identification of mouse histone deacetylase 1 as a growth factor-inducible gene.  |  Bartl, S., et al. 1997. Mol Cell Biol. 17: 5033-43. PMID: 9271381

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Histone Deacetylase 1 (HDAC1) Antibody (10E2) has 161 citations in a variety of scientific publications.

Primary antibodies like Anti-Histone Deacetylase 1 (HDAC1) Antibody (10E2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Histone Deacetylase 1 (HDAC1) Antibody (10E2) Specifications

Alternate Product Name: HDAC1

Product Clone Name: 10E2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 467-482a

Epitope Target: HDAC1

Epitope Species: human

Product Reactivity/Detection: HDAC1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 161 citations in various scientific publications

Available Conjugates/Forms for Histone Deacetylase 1 (HDAC1) Antibody (10E2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent

The preferred Histone Deacetylase 1 antibody is Histone Deacetylase 1 Antibody (H-11): sc-8410.