Histone Deacetylase 1 (HDAC1) Antibody (H-11): sc-8410

HDAC1 Antibody (H-11) is a mouse monoclonal IgG1 kappa light chain antibody specifically engineered to target the C-terminal region of human HDAC1, recognizing amino acids 432-482. HDAC1 monoclonal antibody (H-11) exhibits cross-species reactivity, effectively detecting HDAC1 in mouse, rat, and human samples across a variety of applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). HDAC1 mouse monoclonal antibody (H-11) is available in both non-conjugated form and multiple conjugated variants such as agarose, HRP, PE, FITC, and various Alexa Fluor® conjugates, providing versatile options for diverse experimental needs. HDAC1, also called GON-10, HD1, KDAC1, RPD3, and RPD3L1, plays a pivotal role in the regulation of gene expression by modulating chromatin structure through the removal of acetyl groups from lysine residues on histone proteins, leading to chromatin condensation and transcriptional repression. This enzymatic activity is essential for processes such as cell cycle progression, differentiation, and development. HDAC1 is involved in maintaining genomic stability and regulating various signaling pathways. Dysregulation of HDAC1 has been implicated in numerous diseases, including cancer, neurological disorders, and inflammatory conditions, making HDAC1 a critical target for therapeutic intervention and a key focus in epigenetic research.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Histone Deacetylase 1 (HDAC1) Antibody (H-11) has 98 citations in a variety of scientific publications.

Primary antibodies like Anti-Histone Deacetylase 1 (HDAC1) Antibody (H-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Histone Deacetylase 1 (HDAC1) Antibody (H-11) Specifications

Alternate Product Name: HDAC1

Product Clone Name: H-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 432-482

Epitope Target: HDAC1

Epitope Species: human

Product Reactivity/Detection: HDAC1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 98 citations in various scientific publications

Available Conjugates/Forms for Histone Deacetylase 1 (HDAC1) Antibody (H-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent

The preferred Histone Deacetylase 1 antibody is Histone Deacetylase 1 Antibody (10E2): sc-81598.