HCN3 Antibody (B-12): sc-365451

HCN3 Antibody (B-12) is a mouse monoclonal IgG1 antibody that detects HCN3 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-HCN3 antibody (B-12) targets hyperpolarization-activated, cyclic nucleotide-binding channels, which are crucial for regulating the electrical activity of neurons and cardiac cells. These channels play a significant role in generating spontaneous rhythmic activity, particularly in the brain and heart, where they contribute to pacemaker potentials. HCN3 monoclonal antibody (B-12) recognizes a protein characterized by a unique S4 segment, which contains a series of positively charged amino acids that function as a voltage sensor, allowing the channel to respond to changes in membrane potential. This property is essential for the proper functioning of the heart and brain, as it helps maintain rhythmic electrical activity and ensures effective communication between cells. Expression of HCN3 is predominantly found in the hypothalamus and thalamus, regions that are vital for various physiological processes, including the regulation of sleep, arousal, and cardiovascular function. HCN3 (B-12) antibody enables researchers to gain valuable insights into the role of this protein in health and disease, making this tool indispensable for studies focused on cardiac and neurological functions.

The preferred HCN3 antibody is HCN3 Antibody (A-3): sc-393813.