HCN3 Antibody (A-3): sc-393813

HCN3 Antibody (A-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects HCN3 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-HCN3 antibody (A-3) is available as the non-conjugated form. Hyperpolarization-activated, cyclic nucleotide-binding channels (HCN) are essential for regulating neuronal excitability and cardiac rhythm, and are activated by the binding of intracellular cyclic nucleotides, which is crucial for their function. The HCN family, comprising four members (HCN1-4), features a core transmembrane segment domain along with a C-terminal cyclic nucleotide-binding domain that is 120 amino acids long. HCN channels are predominantly expressed in the brain, heart, thalamus, and testis, where these channels play a vital role in generating spontaneous rhythmic activity. Notably, HCN3 contains a unique segment characterized by a series of positively charged amino acids, known as the S4 region, which functions as the voltage sensor. In the central nervous system, HCN3 and HCN4 are primarily localized in the hypothalamus and thalamus, respectively, highlighting their importance in modulating various physiological processes.

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HCN3 Antibody (A-3) References:

1. Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain.  |  Notomi, T. and Shigemoto, R. 2004. J Comp Neurol. 471: 241-76. PMID: 14991560
2. Endogenous channels in HEK cells and potential roles in HCN ionic current measurements.  |  Varghese, A., et al. 2006. Prog Biophys Mol Biol. 90: 26-37. PMID: 15979128
3. Functional expression of the human HCN3 channel.  |  Stieber, J., et al. 2005. J Biol Chem. 280: 34635-43. PMID: 16043489
4. Functional significance of HCN2/3-mediated I(h) in striatal cells at early developmental stages.  |  Bajorat, R., et al. 2005. J Neurosci Res. 82: 206-13. PMID: 16175581
5. Hyperpolarization-activated cyclic nucleotide-gated cation channels regulate auditory coincidence detection in nucleus laminaris of the chick.  |  Yamada, R., et al. 2005. J Neurosci. 25: 8867-77. PMID: 16192376

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HCN3 Antibody (A-3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-HCN3 Antibody (A-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HCN3 Antibody (A-3) Specifications

Alternate Product Name: HCN3

Product Clone Name: A-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 625-774

Epitope Target: HCN3

Epitope Species: human

Product Reactivity/Detection: HCN3

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for HCN3 Antibody (A-3): N/A