GRK 4 Antibody (A-5): sc-9985
- GRK 4 Antibody (A-5) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 478-497 at the C-terminus of GRK 4 of human origin
- recommended for detection of GRK 4 α, β, γ and δ isoforms of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- available conjugated to agarose for IP
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GRK 4 Antibody (A-5) for WB and IHC(P) applications. These reagents are now offered in bundles with GRK 4 Antibody (A-5) (see ordering information below).
GRK 4 Antibody (A-5) is a mouse monoclonal IgG2b antibody that detects GRK 4 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). GRK 4, a member of the G protein-coupled receptor kinase family, plays a crucial role in the regulation of G protein-coupled receptor signaling by phosphorylating activated receptors, which leads to their desensitization. This process is vital for maintaining cellular responsiveness to external signals, as it prevents overstimulation and allows for the fine-tuning of physiological responses. The proper functioning of GRK 4 is essential in various biological processes, including cardiovascular function and neuronal signaling, and dysregulation of this kinase has been implicated in several diseases, making it a significant target for therapeutic intervention. GRK 4 (A-5) antibody provides a reliable tool for researchers studying the dynamics of G protein signaling pathways and their implications in health and disease.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GRK 4 Antibody (A-5) References:
- The importance of G protein-coupled receptor kinase 4 (GRK4) in pathogenesis of salt sensitivity, salt sensitive hypertension and response to antihypertensive treatment. | Rayner, B. and Ramesar, R. 2015. Int J Mol Sci. 16: 5741-9. PMID: 25775155
- Association between GRK4 and DRD1 gene polymorphisms and hypertension: a meta-analysis. | Zhang, H., et al. 2016. Clin Interv Aging. 11: 17-27. PMID: 26730182
- Genetic variants of GRK4 influence circadian rhythm of blood pressure and response to candesartan in hypertensive patients. | Cao, N., et al. 2021. Clin Exp Hypertens. 43: 597-603. PMID: 33899625
- LncRNA 148400 Promotes the Apoptosis of Renal Tubular Epithelial Cells in Ischemic AKI by Targeting the miR-10b-3p/GRK4 Axis. | Li, X., et al. 2022. Cells. 11: PMID: 36552750
- Dopamine Receptor D1R and D3R and GRK4 Interaction in Hypertension. | Zeng, C., et al. 2023. Yale J Biol Med. 96: 95-105. PMID: 37009199
- Exercise ameliorates skeletal muscle insulin resistance by modulating GRK4-mediated D1R expression. | Tao, Y., et al. 2023. Clin Sci (Lond). 137: 1391-1407. PMID: 37622333
- Effect of GRK4 on renal gastrin receptor regulation in hypertension. | Xia, X., et al. 2023. Clin Exp Hypertens. 45: 2245580. PMID: 37641972
- GRK4, A Potential Link between Hypertension and Breast Cancer. | Yue, W., et al. 2022. J Cell Sci Ther. 13: PMID: 37994311
- Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC) for CYP2D6, ADRB1, ADRB2, ADRA2C, GRK4, and GRK5 Genotypes and Beta-Blocker Therapy. | Duarte, JD., et al. 2024. Clin Pharmacol Ther. 116: 939-947. PMID: 38951961
- A cross-tissue transcriptome-wide association study reveals GRK4 as a novel susceptibility gene for COPD. | Chen, G., et al. 2024. Sci Rep. 14: 28438. PMID: 39558015
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GRK 4 Antibody (A-5) | sc-9985 | 200 µg/ml | $322.00 | |||
GRK 4 Antibody (A-5): m-IgG Fc BP-HRP Bundle | sc-536569 | 200 µg Ab; 10 µg BP | $361.00 | |||
GRK 4 Antibody (A-5): m-IgGκ BP-HRP Bundle | sc-533720 | 200 µg Ab; 40 µg BP | $361.00 | |||
GRK 4 Antibody (A-5): m-IgG2b BP-HRP Bundle | sc-549811 | 200 µg Ab; 10 µg BP | $361.00 | |||
GRK 4 Antibody (A-5) AC | sc-9985 AC | 500 µg/ml, 25% agarose | $424.00 | |||
GRK 4 (A-5) Neutralizing Peptide | sc-9985 P | 100 µg/0.5 ml | $69.00 |