Date published: 2026-4-21

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GRK Antibodies

Santa Cruz Biotechnology supplies a comprehensive collection of GRK Antibodies for studying G protein-coupled receptor kinases (GRKs). GRK Antibodies are compatible with multiple research techniques, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). G protein-coupled receptor kinases play a crucial role in the regulation of cellular signaling pathways by phosphorylating activated G protein-coupled receptors, leading to their desensitization and internalization. This process is vital for maintaining cellular homeostasis and modulating responses to external stimuli. Understanding the function of GRKs is essential for elucidating their involvement in various physiological processes and their implications in diseases such as heart failure, cancer, and neurological disorders. GRK research continues to reveal new insights into cellular regulation mechanisms and potential therapeutic targets. Investigating GRK expression patterns helps researchers better understand their tissue distribution and functional significance. Studying GRK-mediated phosphorylation events provides valuable information about signal transduction pathways. Santa Cruz Biotechnology monoclonal antibodies for GRK research support scientists worldwide in advancing our understanding of cellular signaling mechanisms and disease development.

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GRK Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

GRK 1 Antibody (D11)

sc-56910mouse IgG1 κFL (h)WB, IP, IF, ELISAm, r, h

new

(2)

GRK 1 Antibody (G-8)

sc-8004mouse IgG1 κC-terminal (h)WB, IP, IF, ELISAm, r, h, bovine and avian
11
(7)

GRK 2 Antibody (C-9)

sc-13143mouse IgG2a κ468-689 (h)WB, IP, IF, ELISAm, r, h
58
(14)

GRK 2 Antibody (F-9)

sc-166284mouse IgG1 κ661-699 (h)WB, IP, IF, ELISAm, r, h
2
(6)

GRK 2 Antibody (E-7)

sc-166283mouse IgG2b κ661-689 (h)WB, IP, IF, ELISAm, r, h

new

(1)

GRK 2 Antibody (G-12)

sc-271359mouse IgG2a κ661-699 (h)WB, IP, IF, IHC(P), ELISAm, r, h

new

(2)

GRK 3 Antibody (C-11)

sc-365197mouse IgG1 κ646-688 (h)WB, IP, IF, ELISAm, r, h
3
(4)

GRK 4 Antibody (D-11)

sc-376891mouse IgG1 κ81-150 (h)WB, IP, IF, IHC(P), ELISAm, r, h

new

(2)

GRK 4 Antibody (A-5)

sc-9985mouse IgG1 κC-terminal (h)WB, IP, IF, IHC(P), ELISAm, r, h
3
(4)

GRK 5 Antibody (D-9)

sc-518005mouse IgG2a κ94-157 (h)WB, IP, IF, ELISAm, r, h
14
(2)

GRK 6 Antibody (D-10)

sc-377494mouse IgG1 κ96-165 (h)WB, IP, IF, ELISAh
1
(1)

GRK 6 Antibody (XX-4)

sc-100380mouse IgG2a κ71-170 (h)WB, IP, ELISAm, r, h
4
(5)

GRK 7 Antibody (C-2)

sc-398371mouse IgM κ472-501 (h)WB, IP, IF, ELISAh

new

(2)

GRK 7 Antibody (F-4)

sc-398660mouse IgG2b κ515-537 (h)WB, IP, IF, ELISAh

new

(1)

GRK CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

GRK 1 CRISPR/Cas9 KO Plasmid (h)

sc-406525hGene KnockoutGFP0
(0)

GRK 2 CRISPR/Cas9 KO Plasmid (h)

sc-400558hGene KnockoutGFP0
(0)

GRK 2 HDR Plasmid (h)

sc-400558-HDRhHomology Directed RepairPuromycin0
(0)

GRK 2 Double Nickase Plasmid (h)

sc-400558-NIChGene KnockoutPuromycin0
(0)

GRK 2 Double Nickase Plasmid (h2)

sc-400558-NIC-2hGene KnockoutPuromycin0
(0)

GRK 2 CRISPR/Cas9 KO Plasmid (m)

sc-431016mGene KnockoutGFP0
(0)

GRK 2 HDR Plasmid (m)

sc-431016-HDRmHomology Directed RepairPuromycin0
(0)

GRK 2 Double Nickase Plasmid (m)

sc-431016-NICmGene KnockoutPuromycin0
(0)

GRK 2 Double Nickase Plasmid (m2)

sc-431016-NIC-2mGene KnockoutPuromycin0
(0)

GRK 3 CRISPR/Cas9 KO Plasmid (h)

sc-403415hGene KnockoutGFP0
(0)

GRK 3 HDR Plasmid (h)

sc-403415-HDRhHomology Directed RepairPuromycin0
(0)

GRK 3 Double Nickase Plasmid (h)

sc-403415-NIChGene KnockoutPuromycin0
(0)

GRK 3 Double Nickase Plasmid (h2)

sc-403415-NIC-2hGene KnockoutPuromycin0
(0)

GRK 4 CRISPR/Cas9 KO Plasmid (h)

sc-402816hGene KnockoutGFP0
(0)

GRK 4 Double Nickase Plasmid (h)

sc-402816-NIChGene KnockoutPuromycin0
(0)

GRK 4 Double Nickase Plasmid (h2)

sc-402816-NIC-2hGene KnockoutPuromycin0
(0)

GRK 5 CRISPR/Cas9 KO Plasmid (h)

sc-401285hGene KnockoutGFP0
(0)

GRK 5 HDR Plasmid (h)

sc-401285-HDRhHomology Directed RepairPuromycin0
(0)

GRK 5 Double Nickase Plasmid (h)

sc-401285-NIChGene KnockoutPuromycin0
(0)

GRK 5 Double Nickase Plasmid (h2)

sc-401285-NIC-2hGene KnockoutPuromycin0
(0)

GRK 5 Double Nickase Plasmid (m)

sc-420661-NICmGene KnockoutPuromycin0
(0)

GRK 6 CRISPR/Cas9 KO Plasmid (h)

sc-402061hGene KnockoutGFP0
(0)

GRK 6 HDR Plasmid (h)

sc-402061-HDRhHomology Directed RepairPuromycin0
(0)

GRK 6 Double Nickase Plasmid (h)

sc-402061-NIChGene KnockoutPuromycin0
(0)

GRK 6 Double Nickase Plasmid (h2)

sc-402061-NIC-2hGene KnockoutPuromycin0
(0)

GRK 6 CRISPR/Cas9 KO Plasmid (m)

sc-424026mGene KnockoutGFP0
(0)

GRK 6 HDR Plasmid (m)

sc-424026-HDRmHomology Directed RepairPuromycin0
(0)

GRK CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

GRK 2 CRISPR Activation Plasmid (h)

sc-400558-ACThGene ActivationPuro, Blast, Hygro0
(0)

GRK 3 CRISPR Activation Plasmid (h)

sc-403415-ACThGene ActivationPuro, Blast, Hygro0
(0)

GRK 4 CRISPR Activation Plasmid (h)

sc-402816-ACThGene ActivationPuro, Blast, Hygro0
(0)

GRK 4 CRISPR Activation Plasmid (h2)

sc-402816-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

GRK 5 CRISPR Activation Plasmid (h)

sc-401285-ACThGene ActivationPuro, Blast, Hygro0
(0)

GRK 5 CRISPR Activation Plasmid (h2)

sc-401285-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

GRK 6 CRISPR Activation Plasmid (h)

sc-402061-ACThGene ActivationPuro, Blast, Hygro0
(0)

GRK 6 CRISPR Activation Plasmid (h2)

sc-402061-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

GRK siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

GRK 1 siRNA (h)

sc-29336hGene SilencingN/A0
(0)

GRK 1 shRNA Plasmid (h)

sc-29336-SHhGene SilencingPuromycin0
(0)

GRK 1 shRNA (h) Lentiviral Particles

sc-29336-VhGene SilencingPuromycin0
(0)

GRK 1 siRNA (h2)

sc-36208hGene SilencingN/A0
(0)

GRK 1 siRNA (m)

sc-35512mGene SilencingN/A0
(0)

GRK 1 shRNA Plasmid (h2)

sc-36208-SHhGene SilencingPuromycin0
(0)

GRK 1 shRNA Plasmid (m)

sc-35512-SHmGene SilencingPuromycin0
(0)

GRK 1 shRNA (h2) Lentiviral Particles

sc-36208-VhGene SilencingPuromycin0
(0)

GRK 1 shRNA (m) Lentiviral Particles

sc-35512-VmGene SilencingPuromycin0
(0)

GRK 2 siRNA (h)

sc-29337hGene SilencingN/A
13
(0)

GRK 2 shRNA Plasmid (h)

sc-29337-SHhGene SilencingPuromycin
13
(0)

GRK 2 shRNA (h) Lentiviral Particles

sc-29337-VhGene SilencingPuromycin
13
(0)

GRK 2 siRNA (m)

sc-35513mGene SilencingN/A
2
(0)

GRK 2 shRNA Plasmid (m)

sc-35513-SHmGene SilencingPuromycin
2
(0)

GRK 2 shRNA (m) Lentiviral Particles

sc-35513-VmGene SilencingPuromycin
2
(0)

GRK 2 siRNA (r)

sc-270408rGene SilencingN/A0
(0)

GRK 2 shRNA Plasmid (r)

sc-270408-SHrGene SilencingPuromycin0
(0)

GRK 2 shRNA (r) Lentiviral Particles

sc-270408-VrGene SilencingPuromycin0
(0)

GRK 3 siRNA (h)

sc-35514hGene SilencingN/A0
(0)

GRK 3 shRNA Plasmid (h)

sc-35514-SHhGene SilencingPuromycin0
(0)

GRK 3 shRNA (h) Lentiviral Particles

sc-35514-VhGene SilencingPuromycin0
(0)

GRK 3 siRNA (m)

sc-35515mGene SilencingN/A
1
(0)

GRK 3 shRNA Plasmid (m)

sc-35515-SHmGene SilencingPuromycin
1
(0)

GRK 3 shRNA (m) Lentiviral Particles

sc-35515-VmGene SilencingPuromycin
1
(0)

GRK 4 siRNA (h)

sc-35516hGene SilencingN/A0
(0)

GRK 4 shRNA Plasmid (h)

sc-35516-SHhGene SilencingPuromycin0
(0)

GRK 4 shRNA (h) Lentiviral Particles

sc-35516-VhGene SilencingPuromycin0
(0)

GRK 4 siRNA (m)

sc-35517mGene SilencingN/A0
(0)

GRK 4 shRNA Plasmid (m)

sc-35517-SHmGene SilencingPuromycin0
(0)

GRK 4 shRNA (m) Lentiviral Particles

sc-35517-VmGene SilencingPuromycin0
(0)

GRK 5 siRNA (h)

sc-39042hGene SilencingN/A
1
(0)

GRK 5 shRNA Plasmid (h)

sc-39042-SHhGene SilencingPuromycin
1
(0)

GRK 5 shRNA (h) Lentiviral Particles

sc-39042-VhGene SilencingPuromycin
1
(0)

GRK 5 siRNA (m)

sc-39043mGene SilencingN/A
1
(0)

GRK 5 shRNA Plasmid (m)

sc-39043-SHmGene SilencingPuromycin
1
(0)

GRK 5 shRNA (m) Lentiviral Particles

sc-39043-VmGene SilencingPuromycin
1
(0)

GRK 5 siRNA (r)

sc-270362rGene SilencingN/A
2
(0)

GRK 5 shRNA Plasmid (r)

sc-270362-SHrGene SilencingPuromycin
2
(0)

GRK 5 shRNA (r) Lentiviral Particles

sc-270362-VrGene SilencingPuromycin
2
(0)

GRK 6 siRNA (h)

sc-35518hGene SilencingN/A
1
(0)

GRK 6 shRNA Plasmid (h)

sc-35518-SHhGene SilencingPuromycin
1
(0)

GRK 6 shRNA (h) Lentiviral Particles

sc-35518-VhGene SilencingPuromycin
1
(0)

GRK 6 siRNA (m)

sc-35519mGene SilencingN/A0
(0)

GRK 6 shRNA Plasmid (m)

sc-35519-SHmGene SilencingPuromycin0
(0)

GRK 6 shRNA (m) Lentiviral Particles

sc-35519-VmGene SilencingPuromycin0
(0)

GRK 7 siRNA (h)

sc-60767hGene SilencingN/A0
(0)

GRK 7 shRNA Plasmid (h)

sc-60767-SHhGene SilencingPuromycin0
(0)

GRK 7 shRNA (h) Lentiviral Particles

sc-60767-VhGene SilencingPuromycin0
(0)