GPT Antibody (G-10): sc-271861

GPT Antibody (G-10) is a mouse monoclonal IgG2b antibody that detects glutamate pyruvate transaminase (GPT) in mouse and rat samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-GPT antibody (G-10) is crucial for studying GPT′s role in amino acid metabolism and energy production, as GPT catalyzes the reversible transamination between alanine and 2-oxoglutarate, resulting in the formation of pyruvate and glutamate. GPT (G-10) antibody enables research into enzymatic activity vital for maintaining amino acid and glucose balance in the body, particularly in tissues such as the liver, kidney, and heart where GPT is highly expressed. GPT′s localization in these organs underscores its significance in metabolic processes and utility as a biomarker for liver integrity. With GPT′s ability to interact with various substrates and participate in metabolic pathways, GPT monoclonal antibody (G-10) serves as an essential tool for researchers investigating metabolic disorders and liver function.

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GPT Antibody (G-10) References:

1. Further characterization and validation of gpt delta transgenic mice for quantifying somatic mutations in vivo.  |  Swiger, RR., et al. 2001. Environ Mol Mutagen. 37: 297-303. PMID: 11424179
2. Enhanced spontaneous and benzo(a)pyrene-induced mutations in the lung of Nrf2-deficient gpt delta mice.  |  Aoki, Y., et al. 2007. Cancer Res. 67: 5643-8. PMID: 17575130
3. Integration of in vivo genotoxicity and short-term carcinogenicity assays using F344 gpt delta transgenic rats: in vivo mutagenicity of 2,4-diaminotoluene and 2,6-diaminotoluene structural isomers.  |  Toyoda-Hokaiwado, N., et al. 2010. Toxicol Sci. 114: 71-8. PMID: 20026473
4. AFB(1) -induced mutagenesis of the gpt gene in AS52 cells.  |  Wattanawaraporn, R., et al. 2012. Environ Mol Mutagen. 53: 567-73. PMID: 22733615
5. The serum activities of AP, gamma-GT, GLDH, GPT and CHE after complete biliary obstruction and choledochocaval fistula in the rat.  |  Putzki, H., et al. 1989. Clin Chim Acta. 181: 81-5. PMID: 2566401
6. Chemical structure-related mechanisms underlying in vivo genotoxicity induced by nitrofurantoin and its constituent moieties in gpt delta rats.  |  Kijima, A., et al. 2015. Toxicology. 331: 125-35. PMID: 25772432
7. Mutagenic Effects of Perfluorooctanesulfonic Acid in gpt Delta Transgenic System Are Mediated by Hydrogen Peroxide.  |  Wang, Y., et al. 2015. Environ Sci Technol. 49: 6294-303. PMID: 25875360
8. Quantitative analysis of mutagenicity and carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in F344 gpt delta transgenic rats.  |  Gi, M., et al. 2019. Mutagenesis. 34: 279-287. PMID: 31233596
9. Ginkgolide-Platinum(II) Complex GPt(II) Exhibits Therapeutic Effect on Depression in Mice via Upregulation of DA and 5-HT Neurotransmitters.  |  Yang, T., et al. 2020. Med Sci Monit. 26: e922052. PMID: 32484164
10. Effect of sampling time on somatic and germ cell mutations induced by acrylamide in gpt delta mice.  |  Hagio, S., et al. 2021. Genes Environ. 43: 4. PMID: 33597036

The preferred GPT antibody is GPT Antibody (E-3): sc-374501.