GCAP2 Antibody (F6): sc-53990

GCAP2 Antibody (F6) is a mouse monoclonal IgG2b antibody that detects guanylate cyclase-activating protein 2 (GCAP2) in bovine samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GCAP2 plays a crucial role in the phototransduction pathway, specifically in the retina, where GCAP2 is involved in the regulation of cGMP levels in response to calcium fluctuations. This regulation is vital for the recovery of photoreceptors after exposure to light, ensuring that vision can adapt to changing light conditions. GCAP2 is primarily localized in the outer segments of rod and cone photoreceptors, where GCAP2 interacts with guanylate cyclase to modulate its activity based on intracellular calcium concentrations. Notably, GCAP2 is a product of a gene duplication event related to GCAP1, and while both proteins share over 90% sequence similarity, GCAP2 is uniquely expressed in the retina, highlighting GCAP2′s specialized function in visual signaling. The genes encoding GCAP1 and GCAP2 are located on human chromosome 6p21.1, underscoring their evolutionary relationship and importance in mammalian vision. Anti-GCAP2 antibody (F6) is an essential tool for researchers studying retinal function and the molecular mechanisms underlying phototransduction.

The preferred GCAP2 antibody is GCAP2 Antibody (G-10): sc-166056.