Date published: 2026-6-13

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GCAP2 Inhibitors

GCAP2 Inhibitors function by influencing the intricate web of molecules and proteins in the phototransduction pathway. A significant approach involves targeting the guanylate cyclase enzyme. Inhibitors such as ODQ, NS2028, and Methylene Blue limit the activity of guanylate cyclase, thereby indirectly modulating the actions of GCAP2, which is a key regulator of this enzyme in retinal cells. Another tactic entails the regulation of cGMP levels in the cell. By targeting associated proteins like protein kinase G with compounds like KT5823, one can further shape the cellular impacts arising from GCAP2 function.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

L-NG-Nitroarginine Methyl Ester (L-NAME)

51298-62-5sc-200333
sc-200333A
sc-200333B
1 g
5 g
25 g
$48.00
$107.00
$328.00
45
(1)

Inhibits nitric oxide synthase (NOS), which can indirectly affect guanylate cyclase activity, and hence GCAP2 function.

ODQ

41443-28-1sc-200325
sc-200325A
10 mg
50 mg
$78.00
$222.00
13
(1)

A soluble guanylate cyclase inhibitor. By inhibiting guanylate cyclase, ODQ can indirectly modulate the actions of GCAP2.

NS 2028

204326-43-2sc-202743
5 mg
$149.00
1
(0)

Specifically inhibits guanylate cyclase, which can have repercussions on GCAP2-mediated signaling.

Methylene blue

61-73-4sc-215381B
sc-215381
sc-215381A
25 g
100 g
500 g
$43.00
$104.00
$328.00
3
(1)

Acts on guanylate cyclase, reducing its activity and hence indirectly influencing GCAP2.

LY 83583

91300-60-6sc-200314
sc-200314A
5 mg
25 mg
$82.00
$230.00
3
(1)

Inhibits guanylate cyclase activity, thereby having potential indirect effects on GCAP2 function.

KT5823

126643-37-6sc-3534
sc-3534A
sc-3534B
100 µg
1 mg
5 mg
$182.00
$1228.00
$4895.00
21
(1)

Protein kinase G inhibitor. As GCAP2's role in guanylate cyclase activation can influence cGMP and PKG activity, inhibiting PKG can indirectly influence GCAP2-associated signaling.

Vinpocetine

42971-09-5sc-201204
sc-201204A
sc-201204B
20 mg
100 mg
15 g
$55.00
$214.00
$2400.00
4
(1)

Acts as a PDE1 inhibitor, preventing the breakdown of cGMP. This can influence the balance of cGMP in the cell and indirectly modulate GCAP2's function.

Zaprinast (M&B 22948)

37762-06-4sc-201206
sc-201206A
25 mg
100 mg
$105.00
$250.00
8
(2)

A PDE5 inhibitor which affects cGMP levels. By modulating cGMP concentrations, Zaprinast can indirectly influence GCAP2-associated functions.

Ibudilast

50847-11-5sc-203080
10 mg
$218.00
1
(1)

PDE4 inhibitor, leading to increased cGMP levels. This can indirectly influence GCAP2 functions within the cell.