FGF-15 Antibody (D-9): sc-514647

FGF-15 Antibody (D-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects FGF-15 protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). FGF-15 (D-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FGF-15 protein plays a crucial role in regulating intestinal homeostasis and participates in signaling pathways that control cell proliferation and differentiation. FGF-15 protein is primarily expressed in the intestine and maintains the balance of gut epithelial cells, which is vital for proper digestive function and overall gut health. Dysregulation of FGF-15 protein has been implicated in various gastrointestinal disorders, making FGF-15 an important target for research and therapeutic interventions. Anti-FGF-15 antibody (D-9) enables researchers to gain insights into FGF-15 biological functions and potential implications in health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

FGF-15 Antibody (D-9) References:

1. Regulation of Fgf15 expression in the intestine by glucocorticoid receptor.  |  Jia, K., et al. 2019. Mol Med Rep. 19: 2953-2959. PMID: 30720089
2. FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis.  |  Ji, S., et al. 2019. Dev Cell. 48: 460-474.e9. PMID: 30745141
3. Pharmacologic Modulation of Bile Acid-FXR-FGF15/FGF19 Pathway for the Treatment of Nonalcoholic Steatohepatitis.  |  Schumacher, JD. and Guo, GL. 2019. Handb Exp Pharmacol. 256: 325-357. PMID: 31201553
4. FGF15 improves outcomes after brain dead donor liver transplantation with steatotic and non-steatotic grafts in rats.  |  Gulfo, J., et al. 2020. J Hepatol. 73: 1131-1143. PMID: 32422221
5. FGF15/19 is required for adipose tissue plasticity in response to thermogenic adaptations.  |  Morón-Ros, S., et al. 2021. Mol Metab. 43: 101113. PMID: 33171307
6. Feeding activates FGF15-SHP-TFEB-mediated lipophagy in the gut.  |  Seok, S., et al. 2022. EMBO J. 41: e109997. PMID: 35686465
7. Minocycline-induced disruption of the intestinal FXR/FGF15 axis impairs osteogenesis in mice.  |  Carson, MD., et al. 2023. JCI Insight. 8: PMID: 36413391
8. Roseburia intestinalis relieves intrahepatic cholestasis of pregnancy through bile acid/FXR-FGF15 in rats.  |  Sun, H., et al. 2023. iScience. 26: 108392. PMID: 38025767
9. Ji-Ni-De-Xie ameliorates type 2 diabetes mellitus by modulating the bile acids metabolism and FXR/FGF15 signaling pathway.  |  Tao, Y., et al. 2024. Front Pharmacol. 15: 1383896. PMID: 38835663
10. The role of FGF15/FGF19 in the development of the central nervous system, eyes and inner ears in vertebrates.  |  Hidalgo-Sánchez, M., et al. 2024. Tissue Cell. 91: 102619. PMID: 39579736

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FGF-15 Antibody (D-9) has 16 citations in a variety of scientific publications.

Primary antibodies like Anti-FGF-15 Antibody (D-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FGF-15 Antibody (D-9) Specifications

Alternate Product Name: FGF-15

Product Clone Name: D-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 194-218

Epitope Target: FGF-15

Epitope Species: mouse

Product Reactivity/Detection: precursor and mature FGF-15

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 16 citations in various scientific publications

Available Conjugates/Forms for FGF-15 Antibody (D-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred FGF-15 antibody is FGF-15 Antibody (G-5): sc-398338.