ERK 1 Antibody (G-12): sc-376852

ERK 1 Antibody (G-12) is a mouse monoclonal IgG1 antibody that detects an epitope mapping between amino acids 341-367 at the C-terminus of ERK 1 of rat origin, in mouse, rat, human, chicken, and frog samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Extracellular signal-regulated kinase 1 (ERK 1), also referred to as Mitogen-activated protein kinase 3 (MAPK3), ERT2, Insulin-stimulated MAP2 kinase, MAP kinase isoform p44, and p44 MAP kinase, is a crucial component of the mitogen-activated protein kinase (MAPK) signaling pathways, which play a significant role in cellular processes such as proliferation, differentiation, and transcription regulation. ERK 1 is primarily located in the cytoplasm but translocates to the nucleus upon activation, where ERK 1 influences gene expression and cellular responses. This translocation is vital for the regulation of various biological functions, including cell growth and survival, making ERK 1 a key player in developmental processes and responses to extracellular signals. The human ERK 1 gene, located on chromosome 16p11.2, encodes a 379 amino acid protein that exhibits 83% sequence identity with ERK 2, highlighting the evolutionary conservation and functional importance of this kinase in various species. ERK 1 monoclonal antibody (G-12) is an essential tool for researchers studying MAPK signaling pathways and their implications in health and disease.

The preferred p-ERK antibody is p-ERK Antibody (E-4): sc-7383.