eotaxin Antibody (C-3): sc-373767

eotaxin Antibody (C-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects eotaxin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). eotaxin Antibody (C-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. eotaxin, also known as eotaxin-1, is a crucial member of the C-C or β family of chemokines, distinguished by adjacent cysteine residues, which play a significant role in mediating immune responses. eotaxin is primarily located in the lungs and is secreted by various cell types, including epithelial cells and fibroblasts, in response to inflammatory stimuli. eotaxin′s localization is vital as this chemokine acts as a potent chemoattractant for eosinophils, which are key players in allergic reactions and asthma. Eosinophilia, characterized by an increased number of eosinophils, is a hallmark of several allergic conditions, including bronchial asthma, dermatitis, and conjunctivitis, making eotaxin a critical target for understanding and potentially treating these diseases. CKR-3, identified as the high-affinity receptor for eotaxin, is expressed on the surface of primary eosinophils, underscoring eotaxin′s importance in orchestrating eosinophilic responses in allergic inflammation.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

eotaxin Antibody (C-3) References:

1. IL-4 induces eotaxin in human dermal fibroblasts.  |  Mochizuki, M., et al. 1999. Int Arch Allergy Immunol. 120 Suppl 1: 19-23. PMID: 10529597
2. Eotaxin and eosinophil recruitment: implications for human disease.  |  Rankin, SM., et al. 2000. Mol Med Today. 6: 20-7. PMID: 10637571
3. Eotaxin/CCL11 in idiopathic retroperitoneal fibrosis.  |  Mangieri, D., et al. 2012. Nephrol Dial Transplant. 27: 3875-84. PMID: 23114905
4. Eotaxin-1 is involved in parasite clearance during chronic filarial infection.  |  Gentil, K., et al. 2014. Parasite Immunol. 36: 60-77. PMID: 24112106
5. CCL-11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-Psychiatric Disorders.  |  Ivanovska, M., et al. 2020. Pharmaceuticals (Basel). 13: PMID: 32887304
6. Using interleukin-18, Eotaxin-1, and Eotaxin-3 to identify brain injury in neonates with congenital heart disease.  |  Ghosh, S., et al. 2023. J Neuroimmunol. 385: 578239. PMID: 37976996
7. Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation.  |  Jose, PJ., et al. 1994. J Exp Med. 179: 881-7. PMID: 7509365
8. Eotaxin: cloning of an eosinophil chemoattractant cytokine and increased mRNA expression in allergen-challenged guinea-pig lungs.  |  Jose, PJ., et al. 1994. Biochem Biophys Res Commun. 205: 788-94. PMID: 7999113
9. Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia.  |  Garcia-Zepeda, EA., et al. 1996. Nat Med. 2: 449-56. PMID: 8597956
10. Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils.  |  Ponath, PD., et al. 1996. J Clin Invest. 97: 604-12. PMID: 8609214
11. Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3.  |  Kitaura, M., et al. 1996. J Biol Chem. 271: 7725-30. PMID: 8631813
12. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.  |  Choe, H., et al. 1996. Cell. 85: 1135-48. PMID: 8674119

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-eotaxin Antibody (C-3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-eotaxin Antibody (C-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

eotaxin Antibody (C-3) Specifications

Alternate Product Name: CCL11

Product Clone Name: C-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 71-96

Epitope Target: eotaxin

Epitope Species: human

Product Reactivity/Detection: eotaxin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for eotaxin Antibody (C-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred MCP-1-4/eotaxin antibody is MCP-1-4/eotaxin Antibody (B-2): sc-377082.