Egr-2 Antibody (G-9): sc-518117

Egr-2 Antibody (G-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects Egr-2 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Egr-2 antibody (G-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Egr-2, a sequence-specific DNA-binding transcription factor, plays a crucial role in regulating transcriptional activities that govern cellular growth, differentiation, and function. Egr-2 is particularly important for involvement in the transcriptional regulation of genes such as HoxA4, which is essential for proper embryonic development. Egr-2 is primarily localized in the nucleus, where Egr-2 binds to specific DNA sites in the promoter region, facilitating the expression of target genes. Notably, defects in Egr-2 can lead to congenital hypomyelination neuropathy (CHN), a condition characterized by early onset hypotonia, areflexia, distal muscle weakness, and significantly reduced nerve conduction velocities. Additionally, mutations in the EGR2 gene are implicated in Dejerine-Sottas syndrome (DSS), which presents with severe early onset motor and sensory neuropathy, further underscoring the importance of Egr-2 in maintaining proper neurological function.

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Egr-2 Antibody (G-9) References:

1. Roles of LAG3 and EGR2 in regulatory T cells.  |  Okamura, T., et al. 2012. Ann Rheum Dis. 71 Suppl 2: i96-100. PMID: 22460149
2. Involvement of early growth response-2 (Egr-2) in lipopolysaccharide-induced neuroinflammation.  |  Yan, Y., et al. 2013. J Mol Histol. 44: 249-57. PMID: 23307302
3. The roles of Egr-2 in autoimmune diseases.  |  Zhang, M., et al. 2015. Inflammation. 38: 972-7. PMID: 25381473
4. Early growth response 2 (Egr-2) expression is triggered by NF-κB activation.  |  Nafez, S., et al. 2015. Mol Cell Neurosci. 64: 95-103. PMID: 25553923
5. Emerging roles of Egr2 and Egr3 in the control of systemic autoimmunity.  |  Morita, K., et al. 2016. Rheumatology (Oxford). 55: ii76-ii81. PMID: 27856665
6. Egr2 contributes to age-dependent vulnerability to sevoflurane-induced cognitive deficits in mice.  |  Chen, YR., et al. 2022. Acta Pharmacol Sin. 43: 2828-2840. PMID: 35577909
7. Deletion of TECRL promotes skeletal muscle repair by up-regulating EGR2.  |  Geng, S., et al. 2024. Proc Natl Acad Sci U S A. 121: e2317495121. PMID: 38753506
8. Egr2 drives the differentiation of Ly6Chi monocytes into fibrosis-promoting macrophages in metabolic dysfunction-associated steatohepatitis in mice.  |  Iwata, A., et al. 2024. Commun Biol. 7: 681. PMID: 38831027
9. EGR2 is an epigenomic regulator of phagocytosis and antifungal immunity in alveolar macrophages.  |  Kolostyak, Z., et al. 2024. JCI Insight. 9: PMID: 39042472
10. Transcription factor EGR2 alleviates autoimmune uveitis via activation of GDF15 to modulate the retinal microglial phenotype.  |  Li, W., et al. 2024. Proc Natl Acad Sci U S A. 121: e2316161121. PMID: 39298490

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Egr-2 Antibody (G-9) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Egr-2 Antibody (G-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Egr-2 Antibody (G-9) Specifications

Alternate Product Name: Egr-2

Product Clone Name: G-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 232-250

Epitope Target: Egr-2

Epitope Species: human

Product Reactivity/Detection: Egr-2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Egr-2 Antibody (G-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Egr-2 antibody is Egr-2 Antibody (1G5): sc-293195.