Date published: 2026-3-17

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Egr-2 Inhibitors

Egr-2 Inhibitors, also known as Early Growth Response 2 inhibitors, are a class of chemical compounds designed to target and modulate the activity of the transcription factor Early Growth Response 2 (Egr-2). Transcription factors like Egr-2 play a pivotal role in regulating gene expression by binding to specific DNA sequences and either enhancing or repressing the transcription of target genes. Egr-2 itself is a member of the Early Growth Response (EGR) family of transcription factors and is involved in various cellular processes, including cell proliferation, differentiation, and apoptosis. In normal physiological conditions, Egr-2 helps regulate these processes by controlling the expression of specific genes. Egr-2 Inhibitors are designed to interfere with the activity of Egr-2, primarily by binding to the transcription factor or its associated co-factors, thus preventing it from effectively binding to its target DNA sequences. This disruption in Egr-2's normal function can lead to downstream effects on gene expression patterns and cellular processes. The development of Egr-2 inhibitors is a part of ongoing research into understanding the intricate molecular mechanisms governing gene regulation and cellular functions. These inhibitors hold potential in various scientific and medical contexts, particularly in elucidating the roles of Egr-2 in disease processes and normal development. By selectively manipulating Egr-2 activity, researchers aim to gain insights into the fundamental biology of cells and tissues, potentially opening new avenues for understanding various conditions.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Suberoylanilide Hydroxamic Acid

149647-78-9sc-220139
sc-220139A
100 mg
500 mg
$133.00
$275.00
37
(2)

Vorinostat inhibits EGR-2 by blocking histone deacetylases (HDACs), leading to increased acetylation of histones and altered gene expression, ultimately downregulating EGR-2.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$152.00
$479.00
$632.00
$1223.00
$2132.00
33
(3)

Trichostatin A is an HDAC inhibitor that prevents EGR-2 repression by enhancing histone acetylation, enabling transcription of target genes.

MS-275

209783-80-2sc-279455
sc-279455A
sc-279455B
1 mg
5 mg
25 mg
$24.00
$90.00
$212.00
24
(2)

Entinostat inhibits EGR-2 by selectively targeting HDACs, promoting histone acetylation and modulating gene expression related to EGR-2.

Valproic Acid

99-66-1sc-213144
10 g
$87.00
9
(1)

Valproic acid exerts its inhibitory effect on EGR-2 through HDAC inhibition, resulting in increased histone acetylation and altered gene transcription.

Romidepsin

128517-07-7sc-364603
sc-364603A
1 mg
5 mg
$218.00
$634.00
1
(1)

Romidepsin inhibits EGR-2 by targeting HDACs, leading to the accumulation of acetylated histones and regulation of EGR-2-associated gene expression.

Panobinostat

404950-80-7sc-208148
10 mg
$200.00
9
(1)

Panobinostat is an HDAC inhibitor that disrupts EGR-2 repression by promoting histone acetylation, facilitating the expression of genes regulated by EGR-2.

Belinostat

414864-00-9sc-269851
sc-269851A
10 mg
100 mg
$156.00
$572.00
(1)

Belinostat inhibits EGR-2 via HDAC inhibition, increasing histone acetylation and modifying gene expression related to EGR-2 function.

Scriptaid

287383-59-9sc-202807
sc-202807A
1 mg
5 mg
$64.00
$183.00
11
(2)

Scriptaid targets HDACs, preventing EGR-2 repression through histone acetylation, thereby affecting the transcription of EGR-2-regulated genes.

Sodium Butyrate

156-54-7sc-202341
sc-202341B
sc-202341A
sc-202341C
250 mg
5 g
25 g
500 g
$31.00
$47.00
$84.00
$222.00
19
(3)

Sodium butyrate inhibits EGR-2 through HDAC inhibition, increasing histone acetylation and modifying gene expression relevant to EGR-2 activity.