Date published: 2025-12-7

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Egr-2 Activators

Egr-2, or Early Growth Response 2, belongs to a family of zinc-finger transcription factors that play crucial roles in a wide array of cellular functions. These transcription factors act as molecular switches, turning on or off specific genes in response to various internal or external stimuli. Specifically, Egr-2 is involved in cellular differentiation, proliferation, and response to growth factors. Egr-2 activators are chemical compounds or agents that can enhance or trigger the expression or activity of the Egr-2 transcription factor. By doing so, these activators can influence the myriad processes governed by this molecule.

The chemical nature of Egr-2 activators can be quite diverse. While some might be small molecules, others could be peptides or even larger macromolecules. Their mode of action can also vary; some might bind directly to the Egr-2 protein, altering its conformation or stability, while others might work upstream, affecting the pathways that lead to its expression or activation. The binding sites, affinities, and specificity of these activators can differ significantly, which underscores the need for rigorous studies to unravel their precise mechanisms. It's important to note that the understanding and identification of these activators can open doors to a myriad of scientific explorations, including investigations into cell biology, genetics, and molecular mechanisms. The detailed biochemistry behind how these activators interact with Egr-2 or its associated pathways remains a fertile ground for research and exploration.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$76.00
$150.00
$725.00
$1385.00
$2050.00
73
(3)

Forskolin activates adenylyl cyclase, leading to increased cyclic AMP (cAMP) levels. Elevated cAMP can activate protein kinase A (PKA) which may upregulate Egr-2 expression in certain cell types.

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$40.00
$129.00
$210.00
$490.00
$929.00
119
(6)

PMA activates protein kinase C (PKC). Activation of PKC has been associated with the induction of Egr-2 in various cells.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$65.00
$319.00
$575.00
$998.00
28
(1)

Retinoic acid, a metabolite of Vitamin A, regulates gene expression through nuclear receptors. It can induce Egr-2 expression in some cell lines, possibly as part of differentiation processes.

Hydrogen Peroxide

7722-84-1sc-203336
sc-203336A
sc-203336B
100 ml
500 ml
3.8 L
$30.00
$60.00
$93.00
27
(1)

As a reactive oxygen species (ROS), hydrogen peroxide can activate several intracellular signaling pathways. This can lead to the induction of Egr-2 in certain conditions.

Lovastatin

75330-75-5sc-200850
sc-200850A
sc-200850B
5 mg
25 mg
100 mg
$28.00
$88.00
$332.00
12
(1)

Lovastatin inhibits HMG-CoA reductase, a key enzyme in cholesterol synthesis. This alteration can trigger multiple cellular responses, including the induction of Egr-2 in some settings.

Caffeine

58-08-2sc-202514
sc-202514A
sc-202514B
sc-202514C
sc-202514D
5 g
100 g
250 g
1 kg
5 kg
$32.00
$66.00
$95.00
$188.00
$760.00
13
(1)

Caffeine can induce intracellular calcium release and alter cAMP levels. Through these mechanisms, it might influence Egr-2 expression in certain cell types.

Kainic acid

487-79-6sc-200454
sc-200454A
sc-200454B
sc-200454C
sc-200454D
5 mg
25 mg
100 mg
1 g
5 g
$85.00
$370.00
$1350.00
$7650.00
$24480.00
12
(1)

Kainic acid is a glutamate receptor agonist. Activation of certain glutamate receptors can lead to intracellular signaling changes that induce Egr-2 expression.

2-APB

524-95-8sc-201487
sc-201487A
20 mg
100 mg
$27.00
$52.00
37
(1)

2-APB affects intracellular calcium levels. Changes in calcium signaling can influence the expression of Egr-2 in some cells.

Dexamethasone

50-02-2sc-29059
sc-29059B
sc-29059A
100 mg
1 g
5 g
$76.00
$82.00
$367.00
36
(1)

Dexamethasone is a glucocorticoid that can regulate gene expression. In specific cell types, dexamethasone may induce the expression of Egr-2.