Egr-2, or Early Growth Response 2, belongs to a family of zinc-finger transcription factors that play crucial roles in a wide array of cellular functions. These transcription factors act as molecular switches, turning on or off specific genes in response to various internal or external stimuli. Specifically, Egr-2 is involved in cellular differentiation, proliferation, and response to growth factors. Egr-2 activators are chemical compounds or agents that can enhance or trigger the expression or activity of the Egr-2 transcription factor. By doing so, these activators can influence the myriad processes governed by this molecule.
The chemical nature of Egr-2 activators can be quite diverse. While some might be small molecules, others could be peptides or even larger macromolecules. Their mode of action can also vary; some might bind directly to the Egr-2 protein, altering its conformation or stability, while others might work upstream, affecting the pathways that lead to its expression or activation. The binding sites, affinities, and specificity of these activators can differ significantly, which underscores the need for rigorous studies to unravel their precise mechanisms. It's important to note that the understanding and identification of these activators can open doors to a myriad of scientific explorations, including investigations into cell biology, genetics, and molecular mechanisms. The detailed biochemistry behind how these activators interact with Egr-2 or its associated pathways remains a fertile ground for research and exploration.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to increased cyclic AMP (cAMP) levels. Elevated cAMP can activate protein kinase A (PKA) which may upregulate Egr-2 expression in certain cell types. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC). Activation of PKC has been associated with the induction of Egr-2 in various cells. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a metabolite of Vitamin A, regulates gene expression through nuclear receptors. It can induce Egr-2 expression in some cell lines, possibly as part of differentiation processes. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
As a reactive oxygen species (ROS), hydrogen peroxide can activate several intracellular signaling pathways. This can lead to the induction of Egr-2 in certain conditions. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $28.00 $88.00 $332.00 | 12 | |
Lovastatin inhibits HMG-CoA reductase, a key enzyme in cholesterol synthesis. This alteration can trigger multiple cellular responses, including the induction of Egr-2 in some settings. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine can induce intracellular calcium release and alter cAMP levels. Through these mechanisms, it might influence Egr-2 expression in certain cell types. | ||||||
Kainic acid | 487-79-6 | sc-200454 sc-200454A sc-200454B sc-200454C sc-200454D | 5 mg 25 mg 100 mg 1 g 5 g | $85.00 $370.00 $1350.00 $7650.00 $24480.00 | 12 | |
Kainic acid is a glutamate receptor agonist. Activation of certain glutamate receptors can lead to intracellular signaling changes that induce Egr-2 expression. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-APB affects intracellular calcium levels. Changes in calcium signaling can influence the expression of Egr-2 in some cells. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone is a glucocorticoid that can regulate gene expression. In specific cell types, dexamethasone may induce the expression of Egr-2. | ||||||