E2A Antibody (D-7): sc-133074
- E2A Antibody (D-7) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 1-649 of E2A of human origin
- recommended for detection of E2A isoforms E12 and E47 of human origin by WB, IP, IF, IHC(P) and ELISA
- TransCruz reagent for ChIP application (sc-133074 X, 200 µg/0.1 ml)
- See E2A (G-2): sc-133075 for E2A antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for E2A Antibody (D-7) for WB and IHC(P) applications. These reagents are now offered in bundles with E2A Antibody (D-7) (see ordering information below).
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E2A Antibody (D-7) is a mouse monoclonal IgG1 antibody that detects E2A in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). E2A, a member of the basic helix-loop-helix (bHLH) transcription factor family, plays a crucial role in regulating gene expression during B cell maturation and myogenic differentiation. E2A (D-7) antibody targets nuclear proteins that bind to specific DNA sequences to regulate transcription of target genes essential for cell differentiation and development. Formation of heterodimers between E2A and other bHLH proteins, such as Myo D, enhances functional versatility, allowing fine-tuned expression of muscle-specific genes and influence on lineage commitment. Understanding E2A localization and function is vital, as anti-E2A antibody (D-7) helps reveal roles in normal cellular processes and implications in various diseases, including cancers where dysregulation of transcription factors can lead to aberrant cell growth. E2A (D-7) monoclonal antibody serves as an invaluable tool for researchers studying these critical biological processes and their implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
E2A Antibody (D-7) References:
- The role of E2A-PBX1 in leukemogenesis. | Aspland, SE., et al. 2001. Oncogene. 20: 5708-17. PMID: 11607820
- Oligomeric self-association contributes to E2A-PBX1-mediated oncogenesis. | Lin, CH., et al. 2019. Sci Rep. 9: 4915. PMID: 30894657
- E2A-PBX1 functions as a coactivator for RUNX1 in acute lymphoblastic leukemia. | Pi, WC., et al. 2020. Blood. 136: 11-23. PMID: 32276273
- E2A regulates neural ectoderm fate specification in human embryonic stem cells. | Yi, S., et al. 2020. Development. 147: PMID: 33144398
- E2A Modulates Stemness, Metastasis, and Therapeutic Resistance of Breast Cancer. | López-Menéndez, C., et al. 2021. Cancer Res. 81: 4529-4544. PMID: 34145034
- Relationship between the structure and function of the transcriptional regulator E2A. | Liang, JJ., et al. 2021. J Biol Res (Thessalon). 28: 15. PMID: 34271975
- Loss of thymocyte competition underlies the tumor suppressive functions of the E2a transcription factor in T-ALL. | Parriott, G., et al. 2024. Leukemia. 38: 491-501. PMID: 38155245
- Development of combination therapies with BTK inhibitors and dasatinib to treat CNS-infiltrating E2A-PBX1+/preBCR+ ALL. | Gentile, G., et al. 2024. Blood Adv. 8: 2846-2860. PMID: 38598725
- An Improved Helper Plasmid Containing Deletions Within the E4 and E2a Genes Results in Increased Adeno-Associated Virus Productivity. | van Lieshout, L., et al. 2024. Hum Gene Ther. 35: 767-776. PMID: 39001832
- Transcriptional function of E2A, Ebf1, Pax5, Ikaros and Aiolos analyzed by in vivo acute protein degradation in early B cell development. | Fedl, AS., et al. 2024. Nat Immunol. 25: 1663-1677. PMID: 39179932
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
E2A Antibody (D-7) | sc-133074 | 200 µg/ml | $322.00 | |||
E2A Antibody (D-7): m-IgG Fc BP-HRP Bundle | sc-537340 | 200 µg Ab; 10 µg BP | $361.00 | |||
E2A Antibody (D-7): m-IgGκ BP-HRP Bundle | sc-534582 | 200 µg Ab; 40 µg BP | $361.00 | |||
E2A Antibody (D-7): m-IgG1 BP-HRP Bundle | sc-545144 | 200 µg Ab; 20 µg BP | $361.00 | |||
E2A Antibody (D-7) X | sc-133074 X | 200 µg/0.1 ml | $322.00 |