Dynactin 1 Antibody (E-6): sc-271166
- Dynactin 1 Antibody (E-6) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 964-1263 of Dynactin 1 of human origin
- recommended for detection of p150 and p135 splice variants of Dynactin 1 of human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Dynactin 1 Antibody (E-6) for WB and IHC(P) applications. These reagents are now offered in bundles with Dynactin 1 Antibody (E-6) (see ordering information below).
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Dynactin 1 Antibody (E-6) is a mouse monoclonal IgG2a antibody that detects Dynactin 1 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Dynactin 1 antibody (E-6) enables researchers to study a key component of the dynactin complex, which is essential for the proper functioning of the Dynein motor protein. This complex facilitates the movement of organelles and vesicles along microtubules, thereby ensuring efficient intracellular transport, which is vital for maintaining cellular homeostasis and function. The interaction between Dynactin 1 and Dynein is particularly important in neurons, where Dynactin 1 supports the transport of neurotransmitter-containing vesicles and other essential cargoes, contributing to synaptic function and neuronal health. Dynactin 1 monoclonal antibody (E-6) helps researchers investigate the protein′s role in the assembly of the mitotic spindle during cell division, highlighting Dynactin 1′s importance in both transport and cell cycle regulation. Dynactin 1 (E-6) antibody′s specificity allows researchers to explore diverse roles in cellular processes, making this reagent an invaluable tool for studying neurobiology and cell dynamics.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Dynactin 1 Antibody (E-6) References:
- dnc-1/dynactin 1 knockdown disrupts transport of autophagosomes and induces motor neuron degeneration. | Ikenaka, K., et al. 2013. PLoS One. 8: e54511. PMID: 23408943
- DCTN1 mutation analysis in families with progressive supranuclear palsy-like phenotypes. | Caroppo, P., et al. 2014. JAMA Neurol. 71: 208-15. PMID: 24343258
- A novel DCTN1 mutation with late-onset parkinsonism and frontotemporal atrophy. | Araki, E., et al. 2014. Mov Disord. 29: 1201-4. PMID: 24676999
- Distal hereditary motor neuropathy type 7B with Dynactin 1 mutation. | Hwang, SH., et al. 2016. Mol Med Rep. 14: 3362-8. PMID: 27573046
- Autophagy and Ubiquitin-Proteasome System Coordinate to Regulate the Protein Quality Control of Neurodegenerative Disease-Associated DCTN1. | Wang, N., et al. 2020. Neurotox Res. 37: 48-57. PMID: 31654383
- DCTN1-related Parkinson-plus disorder (Perry syndrome). | Richardson, D., et al. 2020. Pract Neurol. 20: 317-319. PMID: 32434902
- DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation. | Deshimaru, M., et al. 2021. Int J Mol Sci. 22: PMID: 33924373
- Behavioral profile in a Dctn1G71A knock-in mouse model of Perry disease. | Deshimaru, M., et al. 2021. Neurosci Lett. 764: 136234. PMID: 34508845
- Dynactin 1 negatively regulates HIV-1 infection by sequestering the host cofactor CLIP170. | Shanmugapriya, S., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 34686593
- Wild-Type DCTN1 Suppresses the Aggregation of DCTN1 Mutants Associated with Perry Disease. | Fukui, Y., et al. 2024. Biol Pharm Bull. 47: 253-258. PMID: 38267040
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dynactin 1 Antibody (E-6) | sc-271166 | 200 µg/ml | $322.00 | |||
Dynactin 1 Antibody (E-6): m-IgG Fc BP-HRP Bundle | sc-537579 | 200 µg Ab; 10 µg BP | $361.00 | |||
Dynactin 1 Antibody (E-6): m-IgGκ BP-HRP Bundle | sc-534883 | 200 µg Ab; 40 µg BP | $361.00 |