DR4 Antibody (DR4.1): sc-32255

DR4 Antibody (DR4.1) is a mouse monoclonal IgG1 antibody that detects DR4 in human samples through applications such as immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). DR4, also known as Death Receptor 4, is a crucial member of the tumor necrosis factor receptor superfamily and plays a significant role in mediating apoptosis, particularly in response to the cytokine TRAIL (TNF-related apoptosis-inducing ligand). Anti-DR4 antibody (DR4.1) recognizes a death domain in DR4′s cytoplasmic region, which is essential for transmitting apoptotic signals upon ligand binding. This structural feature allows DR4 to interact with various intracellular signaling molecules, leading to the activation of caspases and subsequent programmed cell death. Understanding the structural characteristics of DR4 is vital for elucidating DR4′s function in cancer biology and therapeutic resistance, as alterations in signaling pathways can contribute to tumor survival and proliferation. DR4 (DR4.1) monoclonal antibody serves as an invaluable tool for researchers investigating the mechanisms of apoptosis and the potential therapeutic applications of targeting DR4 in cancer treatment.

The preferred DR4 antibody is DR4 Antibody (B-9): sc-8411.