DOC1 Antibody (D-2): sc-376472
- DOC1 Antibody (D-2) is a mouse monoclonal IgG2b κ DOC1 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 719-753 within an internal region of DOC1 of human origin
- DOC1 Antibody (D-2) is recommended for detection of DOC1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- Anti-DOC1 Antibody (D-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for DOC1 Antibody (D-2) for WB applications. These reagents are now offered in bundles with DOC1 Antibody (D-2) (see ordering information below).
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DOC1 Antibody (D-2) is a mouse monoclonal IgG2b kappa light chain antibody that detects DOC1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DOC1 (D-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DOC1, also known as Down-regulated in Ovarian Cancer-1, Filamin A-interacting protein 1-like, and GPBP-interacting protein, is a 1135 amino acid protein that plays a crucial role in cellular processes, particularly in ovarian cancer, where DOC1 is often downregulated. DOC1 absence in ovarian cancer cell lines highlights potential as a tumor suppressor, and research indicates that knockdown of DOC1 mRNA can lead to suppression of EMAP II-stimulated gene expression, suggesting DOC1 may mediate important signaling pathways. Additionally, DOC1 gene is upregulated in endothelial cells treated with angiogenesis inhibitors, indicating potential utility as an antivascular agent in cancer therapy. Notably, DOC1 exists in five isoforms due to alternative splicing, which may contribute to diverse functional roles in different cellular contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
DOC1 Antibody (D-2) References:
- Gene expression in the spermatogenically inactive 'dark' and maturing 'light' testicular tissues of the prepubertal colt. | Ing, NH., et al. 2004. J Androl. 25: 535-44. PMID: 15223842
- Gene expression profiles in primary ovarian serous papillary tumors and normal ovarian epithelium: identification of candidate molecular markers for ovarian cancer diagnosis and therapy. | Santin, AD., et al. 2004. Int J Cancer. 112: 14-25. PMID: 15305371
- Endothelial monocyte activating polypeptide-II induced gene expression changes in endothelial cells. | Tandle, AT., et al. 2005. Cytokine. 30: 347-58. PMID: 15935955
- Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer. | Zhang, L., et al. 2008. Proc Natl Acad Sci U S A. 105: 7004-9. PMID: 18458333
- Differential gene expression analysis of ovarian cancer in a population isolate. | Grazio, D., et al. 2008. Eur J Gynaecol Oncol. 29: 357-63. PMID: 18714569
- Functional characterization of filamin a interacting protein 1-like, a novel candidate for antivascular cancer therapy. | Kwon, M., et al. 2008. Cancer Res. 68: 7332-41. PMID: 18794120
- Molecular cloning of differentially expressed genes in human epithelial ovarian cancer. | Mok, SC., et al. 1994. Gynecol Oncol. 52: 247-52. PMID: 8314147
- DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer. | Mok, SC., et al. 1998. Oncogene. 16: 2381-7. PMID: 9620555
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DOC1 Antibody (D-2) | sc-376472 | 200 µg/ml | $316.00 | |||
DOC1 Antibody (D-2): m-IgG Fc BP-HRP Bundle | sc-529874 | 200 µg Ab; 10 µg BP | $354.00 | |||
DOC1 Antibody (D-2): m-IgGκ BP-HRP Bundle | sc-522964 | 200 µg Ab, 40 µg BP | $354.00 | |||
DOC1 Antibody (D-2): m-IgG2b BP-HRP Bundle | sc-550147 | 200 µg Ab; 10 µg BP | $354.00 | |||
DOC1 Antibody (D-2) AC | sc-376472 AC | 500 µg/ml, 25% agarose | $416.00 | |||
DOC1 Antibody (D-2) HRP | sc-376472 HRP | 200 µg/ml | $316.00 | |||
DOC1 Antibody (D-2) FITC | sc-376472 FITC | 200 µg/ml | $330.00 | |||
DOC1 Antibody (D-2) PE | sc-376472 PE | 200 µg/ml | $343.00 | |||
DOC1 Antibody (D-2) Alexa Fluor® 488 | sc-376472 AF488 | 200 µg/ml | $357.00 | |||
DOC1 Antibody (D-2) Alexa Fluor® 546 | sc-376472 AF546 | 200 µg/ml | $357.00 | |||
DOC1 Antibody (D-2) Alexa Fluor® 594 | sc-376472 AF594 | 200 µg/ml | $357.00 | |||
DOC1 Antibody (D-2) Alexa Fluor® 647 | sc-376472 AF647 | 200 µg/ml | $357.00 | |||
DOC1 Antibody (D-2) Alexa Fluor® 680 | sc-376472 AF680 | 200 µg/ml | $357.00 | |||
DOC1 Antibody (D-2) Alexa Fluor® 790 | sc-376472 AF790 | 200 µg/ml | $357.00 | |||
DOC1 (D-2) Neutralizing Peptide | sc-376472 P | 100 µg/0.5 ml | $68.00 |