DEPTOR Antibody (E-2): sc-514608

DEPTOR Antibody (E-2) is a mouse monoclonal IgG2a antibody that detects DEPTOR in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DEPTOR, also known as DEP.6 or DEPDC6, is a 409 amino acid protein that plays a crucial role in the regulation of the mTORC1 and mTORC2 signaling pathways, which are essential for cellular growth, proliferation, and survival. By negatively regulating these pathways, DEPTOR helps maintain cellular homeostasis and prevent uncontrolled cell growth, making DEPTOR a significant player in cancer biology and metabolic disorders. DEPTOR is primarily located in the cytoplasm, where DEPTOR interacts with various signaling molecules, including FRAP, through its PDZ domain. This interaction is vital for the modulation of mTOR activity, and any dysregulation in DEPTOR′s function can lead to various diseases, including certain types of cancer and neurological disorders. DEPTOR is encoded by a gene located on human chromosome 8q24.12, a region associated with numerous genetic conditions and malignancies, highlighting the importance of studying DEPTOR in the context of human health and disease. Anti-DEPTOR antibody (E-2) is an invaluable tool for researchers aiming to explore the intricate roles of DEPTOR in cellular signaling and its implications in various pathologies.

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DEPTOR Antibody (E-2) References:

1. DEPTOR suppresses the progression of esophageal squamous cell carcinoma and predicts poor prognosis.  |  Ji, YM., et al. 2016. Oncotarget. 7: 14188-98. PMID: 26893358
2. p65 down-regulates DEPTOR expression in response to LPS stimulation in hepatocytes.  |  Yu, X., et al. 2016. Gene. 589: 12-19. PMID: 27179948
3. DEPTOR maintains plasma cell differentiation and favorably affects prognosis in multiple myeloma.  |  Quwaider, D., et al. 2017. J Hematol Oncol. 10: 92. PMID: 28420429
4. Loss of hepatic DEPTOR alters the metabolic transition to fasting.  |  Caron, A., et al. 2017. Mol Metab. 6: 447-458. PMID: 28462079
5. DEPTOR Prevents Osteoarthritis Development Via Interplay With TRC8 to Reduce Endoplasmic Reticulum Stress in Chondrocytes.  |  Li, K., et al. 2021. J Bone Miner Res. 36: 400-411. PMID: 32916025
6. DEPTOR inhibits lung tumorigenesis by inactivating the EGFR-mTOR signals.  |  Gong, L., et al. 2021. Cancer Lett. 519: 263-276. PMID: 34320372
7. DEPTOR exacerbates bone-fat imbalance in osteoporosis by transcriptionally modulating BMSC differentiation.  |  Ouyang, Z., et al. 2022. Biomed Pharmacother. 151: 113164. PMID: 35609371
8. DEPTOR loss impairs brown adipocyte development in vitro but has limited impacts in mice.  |  Colas, C., et al. 2023. Mol Metab. 67: 101660. PMID: 36535626
9. DEPTOR as a novel prognostic marker inhibits the proliferation via deactivating mTOR signaling pathway in gastric cancer cells.  |  Ma, G., et al. 2023. Exp Cell Res. 427: 113598. PMID: 37054772
10. DEPTOR attenuates asthma progression by suppressing endoplasmic reticulum stress through SOD1.  |  Wang, H., et al. 2024. Biol Direct. 19: 114. PMID: 39533404

The preferred DEPTOR antibody is DEPTOR Antibody (A-3): sc-398169.