DEPTOR Antibody (D-2): sc-514609

DEPTOR Antibody (D-2) is a mouse monoclonal IgG1 antibody that detects DEPTOR in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DEPTOR, also known as DEP.6 or DEPDC6, is a 409 amino acid protein that plays a crucial role in regulating mTORC1 and mTORC2 signaling pathways, which are essential for cellular growth, proliferation, and survival. By negatively regulating these pathways, DEPTOR helps maintain cellular homeostasis and prevent uncontrolled cell growth, making DEPTOR a significant player in cancer biology and metabolic disorders. DEPTOR is primarily located in the cytoplasm, where DEPTOR interacts with various signaling molecules, including FRAP, through its PDZ domain. This interaction is vital for proper functioning of mTOR pathways, as DEPTOR influences cellular responses to nutrients and growth factors. DEPTOR undergoes post-translational modifications, including phosphorylation, which can further modulate activity and interactions, highlighting the importance of these modifications in cellular signaling. Anti-DEPTOR antibody (D-2) is an invaluable tool for researchers studying intricate mechanisms of mTOR signaling and implications in various diseases, including cancer and metabolic syndromes.

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DEPTOR Antibody (D-2) References:

1. DEPTOR regulates osteogenic differentiation via inhibiting MEG3-mediated activation of BMP4 signaling and is involved in osteoporosis.  |  Chen, S., et al. 2018. Stem Cell Res Ther. 9: 185. PMID: 29973283
2. DEPTOR inhibits cell proliferation and confers sensitivity to dopamine agonist in pituitary adenoma.  |  Yao, H., et al. 2019. Cancer Lett. 459: 135-144. PMID: 31176743
3. DEPTOR polymorphisms influence late complications in Type 2 diabetes patients.  |  Klen, J., et al. 2019. Pharmacogenomics. 20: 879-890. PMID: 31453770
4. DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals.  |  Chen, X., et al. 2020. Oncogene. 39: 1557-1571. PMID: 31685947
5. miRNA-182/Deptor/mTOR axis regulates autophagy to reduce intestinal ischaemia/reperfusion injury.  |  Li, Y., et al. 2020. J Cell Mol Med. 24: 7873-7883. PMID: 32510855
6. DEPTOR is a direct p53 target that suppresses cell growth and chemosensitivity.  |  Cui, D., et al. 2020. Cell Death Dis. 11: 976. PMID: 33184290
7. Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace.  |  Heimhalt, M., et al. 2021. Elife. 10: PMID: 34519269
8. Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation.  |  Vega, M., et al. 2022. J Biol Chem. 298: 101750. PMID: 35216969
9. Stabilization of DEPTOR sensitizes hypopharyngeal cancer to radiotherapy via targeting degradation.  |  Wang, X., et al. 2022. Mol Ther Oncolytics. 26: 330-346. PMID: 36090478
10. Deptor protects against myocardial ischemia-reperfusion injury by regulating the mTOR signaling and autophagy.  |  Duan, Q., et al. 2024. Cell Death Discov. 10: 508. PMID: 39702468

The preferred DEPTOR antibody is DEPTOR Antibody (A-3): sc-398169.