Cytokeratin 10/13 Antibody (DE-K13): sc-6258
- Cytokeratin 10/13 Antibody (DE-K13) is a mouse monoclonal IgG2a κ, cited in 12 publications, provided at 200 µg/ml
- raised against Cytoskeletal preparation extracted from human ectocervical epithelium
- recommended for detection of Cytokeratin 10 and Cytokeratin 13 of human origin by WB, IP, IF and IHC(P); specific for Cytokeratin 13 by IHC(P)
- See Cytokeratin 10 (LH2): sc-53252 for Cytokeratin 10/13 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Cytokeratin 10/13 Antibody (DE-K13) for WB and IHC(P) applications. These reagents are now offered in bundles with Cytokeratin 10/13 Antibody (DE-K13) (see ordering information below).
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Cytokeratin 10/13 Antibody (DE-K13) is a mouse monoclonal IgG2a antibody that detects Cytokeratin 10/13 in human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Cytokeratin 10/13 antibody (DE-K13) recognizes crucial components of the cytoskeletal structure in epithelial cells, contributing to mechanical resilience and tissue integrity. Cytokeratin 10/13 proteins are primarily located in the cytoplasm of epithelial cells, providing structural support and playing a vital role in cellular processes such as differentiation and apoptosis. Cytokeratin 10/13 can serve as important biomarkers for various types of cancers, with notably elevated expression in certain squamous cell carcinomas, making Cytokeratin 10/13 monoclonal antibody (DE-K13) valuable in diagnosis and tumor characterization. Cytokeratin 10/13′s interaction with proteins like desmoplakin and plakoglobin is essential for maintaining cell-cell adhesion and tissue architecture, underscoring their importance in both normal physiology and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Cytokeratin 10/13 Antibody (DE-K13) References:
- Cytokeratin 10/13, 14, 7, 8, and 18 in invasive squamous cell carcinoma and adenocarcinoma of the uterine cervix. | Heatley, MK. 1999. J Clin Pathol. 52: 789. PMID: 10674044
- Multivariate analyses of Ki-67, cytokeratin 13 and cytokeratin 17 in diagnosis and prognosis of oral precancerous lesions. | Yagyuu, T., et al. 2015. J Oral Pathol Med. 44: 523-31. PMID: 25243470
- Loss of cytokeratin 10 indicates malignant transformation in actinic cheilitis. | Garcia, NG., et al. 2016. Clin Oral Investig. 20: 745-52. PMID: 26264639
- Expression of Cytokeratin 13, 14, 17, and 19 in 4-nitroquinoline-1-oxide-induced Oral Carcinogenesis in Rat. | Saitoh, T., et al. 2016. Bull Tokyo Dent Coll. 57: 241-251. PMID: 28049972
- Kallikrein-Mediated Cytokeratin 10 Degradation Is Required for Varicella Zoster Virus Propagation in Skin. | Tommasi, C., et al. 2020. J Invest Dermatol. 140: 774-784.e11. PMID: 31626786
- Cytokeratin 13 Is a New Biomarker for the Diagnosis of Limbal Stem Cell Deficiency. | Liang, Q., et al. 2022. Cornea. 41: 867-873. PMID: 34743102
- Cytokeratin 13 promotes radiotherapy sensitivity of nasopharyngeal carcinoma by downregulating the MEK/ERK pathway. | Shi, M., et al. 2022. IUBMB Life. 74: 543-553. PMID: 35426961
- Cytokeratin 10 (CK10) expression in cancer: A tissue microarray study on 11,021 tumors. | Uhlig, R., et al. 2022. Ann Diagn Pathol. 60: 152029. PMID: 36029589
- Cytokeratin 13 (CK13) expression in cancer: a tissue microarray study on 10,439 tumors. | Lennartz, M., et al. 2023. APMIS. 131: 77-91. PMID: 36269681
- Expression of cytokeratin 10, 13, and involucrin as prognostic factors in low stage squamous cell carcinoma of the uterine cervix. | van Bommel, PF., et al. 1994. Cancer. 74: 2314-20. PMID: 7522949
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cytokeratin 10/13 Antibody (DE-K13) | sc-6258 | 200 µg/ml | $322.00 | |||
Cytokeratin 10/13 Antibody (DE-K13): m-IgG Fc BP-HRP Bundle | sc-536549 | 200 µg Ab; 10 µg BP | $361.00 | |||
Cytokeratin 10/13 Antibody (DE-K13): m-IgGκ BP-HRP Bundle | sc-533700 | 200 µg Ab; 40 µg BP | $361.00 | |||
Cytokeratin 10/13 Antibody (DE-K13): m-IgG2a BP-HRP Bundle | sc-547835 | 200 µg Ab; 10 µg BP | $361.00 |