Cytokeratin 10 Antibody (LH2): sc-53252

Cytokeratin 10 Antibody (LH2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Cytokeratin 10 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Cytokeratin 10 antibody (LH2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cytokeratin 10 forms a heterotetramer with keratin 1 in epithelial cells, contributing to cytoskeletal structure and mechanical resilience. Cytokeratin 10 is predominantly located in suprabasal layers of the epidermis, including the stratum corneum, and plays a vital role in keratinocyte differentiation. Expression of Cytokeratin 10 helps protect against environmental stressors and contributes to skin barrier function. Cytokeratin 10 serves as a marker for squamous cell carcinomas, aiding in characterization and diagnosis of malignant tumors. Cytokeratin 10 monoclonal antibody (LH2) enables researchers to gain valuable insights into epithelial cell behavior and pathology, making this antibody essential for basic and clinical research.

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Cytokeratin 10 Antibody (LH2) References:

1. [The evaluation of the relationship between malignancy grade and cytokeratin-10 accumulation in human skin squamous cell carcinoma].  |  Osiecka, BJ., et al. 2001. Przegl Lek. 58: 435-8. PMID: 11603178
2. Staphylococcus aureus clumping factor B (ClfB) promotes adherence to human type I cytokeratin 10: implications for nasal colonization.  |  O'Brien, LM., et al. 2002. Cell Microbiol. 4: 759-70. PMID: 12427098
3. Clumping factor B, a fibrinogen-binding MSCRAMM (microbial surface components recognizing adhesive matrix molecules) adhesin of Staphylococcus aureus, also binds to the tail region of type I cytokeratin 10.  |  Walsh, EJ., et al. 2004. J Biol Chem. 279: 50691-9. PMID: 15385531
4. Cytokeratin 10-negative nested pattern enables sure distinction of clonal seborrheic keratosis from pagetoid Bowen's disease.  |  Böer-Auer, A., et al. 2012. J Cutan Pathol. 39: 225-33. PMID: 22236073
5. Molecular mimicry between HSP 65 of Mycobacterium leprae and cytokeratin 10 of the host keratin; role in pathogenesis of leprosy.  |  Singh, I., et al. 2012. Cell Immunol. 278: 63-75. PMID: 23121977
6. Kallikrein-Mediated Cytokeratin 10 Degradation Is Required for Varicella Zoster Virus Propagation in Skin.  |  Tommasi, C., et al. 2020. J Invest Dermatol. 140: 774-784.e11. PMID: 31626786
7. Cytokeratin 10 (CK10) expression in cancer: A tissue microarray study on 11,021 tumors.  |  Uhlig, R., et al. 2022. Ann Diagn Pathol. 60: 152029. PMID: 36029589
8. Expression of cytokeratin 10, 13, and involucrin as prognostic factors in low stage squamous cell carcinoma of the uterine cervix.  |  van Bommel, PF., et al. 1994. Cancer. 74: 2314-20. PMID: 7522949
9. Evaluation of laminin and cytokeratin-10 expression in squamous cell carcinoma of the skin.  |  Osiecka, BJ., et al. 1997. Folia Histochem Cytobiol. 35: 121-2. PMID: 9151104
10. Localization of cytokeratin 10 mRNA in human epidermis using nonradioactive in situ hybridization as a routine method.  |  Meinhold-Heerlein, I., et al. 1998. Arch Dermatol Res. 290: 286-8. PMID: 9681682

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Cytokeratin 10 Antibody (LH2) has 23 citations in a variety of scientific publications.

Primary antibodies like Anti-Cytokeratin 10 Antibody (LH2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Cytokeratin 10 Antibody (LH2) Specifications

Alternate Product Name: Keratin 10

Product Clone Name: LH2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Cytokeratin 10

Epitope Species: human

Product Reactivity/Detection: Cytokeratin 10

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 23 citations in various scientific publications

Available Conjugates/Forms for Cytokeratin 10 Antibody (LH2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Cytokeratin 10 antibody is Cytokeratin 10 Antibody (RKSE60): sc-23877.