CUL-7 Antibody (AB13): sc-53809

CUL-7 Antibody (AB13) is a mouse monoclonal IgG2a antibody that detects CUL-7 in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP) applications. CUL-7 is a crucial member of the Cullin protein family, which plays a significant role in the ubiquitin-proteasome system, specifically in the selective targeting of proteins for ubiquitin-mediated degradation. This process is vital for regulating various cellular functions, including cell cycle progression, differentiation, and response to stress. CUL-7 is primarily located in the cytoplasm and is part of an SCF-like complex that includes RBX1, SKP1, FBXW8, and GLMN isoform 1, facilitating the ubiquitination of target proteins. Proper functioning of CUL-7 is essential, as dysregulation can lead to severe developmental disorders; for instance, mutations in the CUL-7 gene are associated with 3-M syndrome, characterized by significant growth retardation and skeletal abnormalities. CUL-7 is highly expressed in fetal kidney and adult skeletal muscle, with notable expression in the fetal brain, pancreas, kidney, placenta, and heart, highlighting its importance in both developmental and adult physiology. Anti-CUL-7 antibody (AB13) is an invaluable tool for researchers investigating CUL-7′s role in cellular processes and its implications in various diseases.

The preferred CUL-7 antibody is CUL-7 Antibody (AB38): sc-53810.