CUL-7 Antibody (AB38): sc-53810
- CUL-7 Antibody (AB38) is a mouse monoclonal IgG2b κ CUL-7 antibody, cited in 3 publications, provided at 200 µg/ml
- Anti-CUL-7 Antibody (AB38) is recommended for detection of CUL-7 and PARC of mouse, rat and human origin by WB, IP, IF and IHC(P)
- CUL-7 Antibody (AB38) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for CUL-7 Antibody (AB38) for WB and IHC(P) applications. These reagents are now offered in bundles with CUL-7 Antibody (AB38) (see ordering information below).
CUL-7 Antibody (AB38) is a mouse monoclonal IgG2b kappa light chain antibody that detects CUL-7 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-CUL-7 antibody (AB38) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CUL-7 plays a crucial role in the ubiquitin-proteasome pathway, specifically mediating the third step of ubiquitin conjugation as part of an SCF-like complex that includes CUL-7, RBX1, SKP1, FBXW8, and GLMN isoform 1. This complex is essential for the selective degradation of proteins involved in cellular proliferation and differentiation, highlighting its importance in maintaining cellular homeostasis and regulating developmental processes. CUL-7 is predominantly expressed in fetal kidney and adult skeletal muscle, with significant levels also found in fetal brain, adult pancreas, kidney, placenta, and heart, as well as in various cell types such as trophoblasts, lymphoblasts, osteoblasts, chondrocytes, and skin fibroblasts. Notably, mutations in the CUL-7 gene are associated with 3-M syndrome, an autosomal recessive disorder characterized by severe growth retardation and distinctive skeletal abnormalities, underscoring CUL-7′s critical role in normal development.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CUL-7 Antibody (AB38) References:
- CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. | Dias, DC., et al. 2002. Proc Natl Acad Sci U S A. 99: 16601-6. PMID: 12481031
- Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis. | Arai, T., et al. 2003. Proc Natl Acad Sci U S A. 100: 9855-60. PMID: 12904573
- Dimerization of CUL7 and PARC is not required for all CUL7 functions and mouse development. | Skaar, JR., et al. 2005. Mol Cell Biol. 25: 5579-89. PMID: 15964813
- Identification of mutations in CUL7 in 3-M syndrome. | Huber, C., et al. 2005. Nat Genet. 37: 1119-24. PMID: 16142236
- Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function. | Andrews, P., et al. 2006. Oncogene. 25: 4534-48. PMID: 16547496
- A novel p53-binding domain in CUL7. | Kasper, JS., et al. 2006. Biochem Biophys Res Commun. 348: 132-8. PMID: 16875676
- Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development. | Tsunematsu, R., et al. 2006. Mol Cell Biol. 26: 6157-69. PMID: 16880526
- cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. | Kipreos, ET., et al. 1996. Cell. 85: 829-39. PMID: 8681378
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CUL-7 Antibody (AB38) | sc-53810 | 200 µg/ml | $316.00 | |||
CUL-7 Antibody (AB38): m-IgG Fc BP-HRP Bundle | sc-525616 | 200 µg Ab; 10 µg BP | $354.00 | |||
CUL-7 Antibody (AB38): m-IgG2b BP-HRP Bundle | sc-549595 | 200 µg Ab; 10 µg BP | $354.00 | |||
CUL-7 Antibody (AB38) AC | sc-53810 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CUL-7 Antibody (AB38) HRP | sc-53810 HRP | 200 µg/ml | $316.00 | |||
CUL-7 Antibody (AB38) FITC | sc-53810 FITC | 200 µg/ml | $330.00 | |||
CUL-7 Antibody (AB38) PE | sc-53810 PE | 200 µg/ml | $343.00 | |||
CUL-7 Antibody (AB38) Alexa Fluor® 488 | sc-53810 AF488 | 200 µg/ml | $357.00 | |||
CUL-7 Antibody (AB38) Alexa Fluor® 546 | sc-53810 AF546 | 200 µg/ml | $357.00 | |||
CUL-7 Antibody (AB38) Alexa Fluor® 594 | sc-53810 AF594 | 200 µg/ml | $357.00 | |||
CUL-7 Antibody (AB38) Alexa Fluor® 647 | sc-53810 AF647 | 200 µg/ml | $357.00 | |||
CUL-7 Antibody (AB38) Alexa Fluor® 680 | sc-53810 AF680 | 200 µg/ml | $357.00 | |||
CUL-7 Antibody (AB38) Alexa Fluor® 790 | sc-53810 AF790 | 200 µg/ml | $357.00 |