CUL-3 Antibody (H-1): sc-166053

CUL-3 Antibody (H-1) is a mouse monoclonal IgG1 antibody that detects CUL-3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CUL-3 plays a crucial role in the ubiquitin-proteasome system, specifically in the selective degradation of proteins, which is vital for maintaining cellular homeostasis and regulating various biological processes, including the cell cycle and signal transduction. CUL-3 forms a part of the E3 ubiquitin ligase complex, where CUL-3 associates with other proteins to facilitate the ubiquitination of target substrates. CUL-3 interacts with specific BTB (Broad-Complex, Tramtrack, and Bric-a-brac) domain-containing proteins, which serve as substrate adaptors, allowing CUL-3 to recognize and ubiquitinate a diverse array of proteins, including those involved in cell cycle regulation and transcriptional control. CUL-3′s ability to modulate protein levels is essential for processes such as cellular differentiation and response to stress, highlighting CUL-3′s importance in both normal physiology and disease states. Anti-CUL-3 antibody (H-1) is an invaluable tool for researchers exploring protein degradation mechanisms and their implications in various biological contexts.

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CUL-3 Antibody (H-1) References:

1. Mechanisms and controversies in mutant Cul3-mediated familial hyperkalemic hypertension.  |  Ferdaus, MZ. and McCormick, JA. 2018. Am J Physiol Renal Physiol. 314: F915-F920. PMID: 29361671
2. Molecular basis of cullin-3 (Cul3) ubiquitin ligase subversion by vaccinia virus protein A55.  |  Gao, C., et al. 2019. J Biol Chem. 294: 6416-6429. PMID: 30819806
3. CUL3 (cullin 3)-mediated ubiquitination and degradation of BECN1 (beclin 1) inhibit autophagy and promote tumor progression.  |  Li, X., et al. 2021. Autophagy. 17: 4323-4340. PMID: 33977871
4. Current trends of high-risk gene Cul3 in neurodevelopmental disorders.  |  Lin, P., et al. 2023. Front Psychiatry. 14: 1215110. PMID: 37575562
5. Insights into the diverse mechanisms and effects of variant CUL3-induced familial hyperkalemic hypertension.  |  Sharma, P. and Chatrathi, HE. 2023. Cell Commun Signal. 21: 286. PMID: 37845702
6. JunD-miR494-CUL3 axis promotes radioresistance and metastasis by facilitating EMT and restraining PD-L1 degradation in esophageal squamous cell carcinoma.  |  Li, X., et al. 2024. Cancer Lett. 587: 216731. PMID: 38369005
7. Oncogenic mutations of KRAS modulate its turnover by the CUL3/LZTR1 E3 ligase complex.  |  Damianou, A., et al. 2024. Life Sci Alliance. 7: PMID: 38453365
8. Structure and dynamics of a pentameric KCTD5/CUL3/Gβγ E3 ubiquitin ligase complex.  |  Nguyen, DM., et al. 2024. Proc Natl Acad Sci U S A. 121: e2315018121. PMID: 38625940
9. A conserved N-terminal motif of CUL3 contributes to assembly and E3 ligase activity of CRL3KLHL22.  |  Wang, W., et al. 2024. Nat Commun. 15: 3789. PMID: 38710693
10. Loss-of-Function Variants in CUL3 Cause a Syndromic Neurodevelopmental Disorder.  |  Blackburn, PR., et al. 2024. Ann Neurol.. PMID: 39301775

The preferred CUL-3 antibody is CUL-3 Antibody (G-8): sc-166110.