CSN8 Antibody (C-9): sc-514088
- CSN8 Antibody (C-9) is a mouse monoclonal IgG2b κ CSN8 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 161-186 near the C-terminus of CSN8 of mouse origin
- CSN8 Antibody (C-9) is recommended for detection of CSN8 of mouse and rat origin by WB, IP, IF and ELISA
- Anti-CSN8 Antibody (C-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CSN8 Antibody (C-9) for WB applications. These reagents are now offered in bundles with CSN8 Antibody (C-9) (see ordering information below).
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CSN8 Antibody (C-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects CSN8 protein of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CSN8 (C-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CSN8 is a crucial component of the COP9 signalosome (CSN) complex, which plays a significant role in regulating the ubiquitin-proteasome pathway, a vital process for maintaining cellular homeostasis and regulating protein degradation. The CSN complex, composed of several proteins including CSN1 (COPS1), CSN2 (COPS2), CSN3 (COPS3), CSN4 (COPS4), CSN5 (COPS5), CSN6 (COP6), CSN7a (COPS7, COPS7a), CSN7b (COP7b), and CSN8 (COP8), is essential for the deneddylation of SCF-type E3 ligase complexes, which in turn decreases their ubiquitin ligase activity. This regulation is critical for various cellular processes, including cell cycle progression and response to stress signals. CSN8 is involved in the phosphorylation of key proteins such as p53, c-Jun, IκBα, and IRF-8, which are important for cell survival and apoptosis. CSN8′s ability to modulate these pathways highlights its importance in cellular signaling and potential implications in cancer and other diseases where protein degradation is dysregulated.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CSN8 Antibody (C-9) | sc-514088 | 200 µg/ml | $322.00 | |||
CSN8 Antibody (C-9): m-IgG Fc BP-HRP Bundle | sc-531027 | 200 µg Ab; 10 µg BP | $361.00 | |||
CSN8 Antibody (C-9): m-IgGκ BP-HRP Bundle | sc-524602 | 200 µg Ab, 40 µg BP | $361.00 | |||
CSN8 Antibody (C-9): m-IgG2b BP-HRP Bundle | sc-550252 | 200 µg Ab; 10 µg BP | $361.00 | |||
CSN8 Antibody (C-9) AC | sc-514088 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CSN8 Antibody (C-9) HRP | sc-514088 HRP | 200 µg/ml | $322.00 | |||
CSN8 Antibody (C-9) FITC | sc-514088 FITC | 200 µg/ml | $336.00 | |||
CSN8 Antibody (C-9) PE | sc-514088 PE | 200 µg/ml | $349.00 | |||
CSN8 Antibody (C-9) Alexa Fluor® 488 | sc-514088 AF488 | 200 µg/ml | $364.00 | |||
CSN8 Antibody (C-9) Alexa Fluor® 546 | sc-514088 AF546 | 200 µg/ml | $364.00 | |||
CSN8 Antibody (C-9) Alexa Fluor® 594 | sc-514088 AF594 | 200 µg/ml | $364.00 | |||
CSN8 Antibody (C-9) Alexa Fluor® 647 | sc-514088 AF647 | 200 µg/ml | $364.00 | |||
CSN8 Antibody (C-9) Alexa Fluor® 680 | sc-514088 AF680 | 200 µg/ml | $364.00 | |||
CSN8 Antibody (C-9) Alexa Fluor® 790 | sc-514088 AF790 | 200 µg/ml | $364.00 | |||
CSN8 (C-9) Neutralizing Peptide | sc-514088 P | 100 µg/0.5 ml | $69.00 |