CSN8 Antibody (F-8): sc-393482
- CSN8 Antibody (F-8) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-209 representing full length CSN8 of human origin
- Anti-CSN8 Antibody (F-8) is recommended for detection of CSN8 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-CSN8 Antibody (F-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CSN8 Antibody (F-8) for WB applications. These reagents are now offered in bundles with CSN8 Antibody (F-8) (see ordering information below).
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CSN8 Antibody (F-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects CSN8 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CSN8 (F-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CSN8 is a crucial component of the COP9 signalosome (CSN) complex, which plays a significant role in regulating the ubiquitin-proteasome pathway, a vital process for maintaining cellular homeostasis and regulating protein degradation. The CSN complex, composed of several proteins including CSN1 (COPS1), CSN2 (COPS2), CSN3 (COPS3), CSN4 (COPS4), CSN5 (COPS5), CSN6 (COP6), CSN7a (COPS7, COPS7a), CSN7b (COP7b), and CSN8 (COP8), is essential for the deneddylation of SCF-type E3 ligase complexes, which in turn decreases ubiquitin ligase activity. This regulation is critical for various cellular processes, including cell cycle progression and response to stress signals. CSN8 is involved in the phosphorylation of key proteins such as p53, c-Jun, IκBα, and IRF-8, which are important for cell survival and apoptosis. CSN8′s ability to modulate these pathways highlights its importance in cellular signaling and potential implications in cancer and other diseases where these pathways are dysregulated.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CSN8 Antibody (F-8) References:
- Arabidopsis eIF3e (INT-6) associates with both eIF3c and the COP9 signalosome subunit CSN7. | Yahalom, A., et al. 2001. J Biol Chem. 276: 334-40. PMID: 11029466
- COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. | Bech-Otschir, D., et al. 2001. EMBO J. 20: 1630-9. PMID: 11285227
- Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. | Lyapina, S., et al. 2001. Science. 292: 1382-5. PMID: 11337588
- Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. | Uhle, S., et al. 2003. EMBO J. 22: 1302-12. PMID: 12628923
- The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. | Groisman, R., et al. 2003. Cell. 113: 357-67. PMID: 12732143
- Gene structure and embryonic expression of mouse COP9 signalosome subunit 8 (Csn8). | Lykke-Andersen, K. and Wei, N. 2003. Gene. 321: 65-72. PMID: 14636993
- A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. | Seeger, M., et al. 1998. FASEB J. 12: 469-78. PMID: 9535219
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CSN8 Antibody (F-8) | sc-393482 | 200 µg/ml | $322.00 | |||
CSN8 Antibody (F-8): m-IgGκ BP-HRP Bundle | sc-523959 | 200 µg Ab, 40 µg BP | $361.00 | |||
CSN8 Antibody (F-8): m-IgG1 BP-HRP Bundle | sc-533630 | 200 µg Ab; 20 µg BP | $361.00 | |||
CSN8 Antibody (F-8) AC | sc-393482 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CSN8 Antibody (F-8) HRP | sc-393482 HRP | 200 µg/ml | $322.00 | |||
CSN8 Antibody (F-8) FITC | sc-393482 FITC | 200 µg/ml | $336.00 | |||
CSN8 Antibody (F-8) PE | sc-393482 PE | 200 µg/ml | $349.00 | |||
CSN8 Antibody (F-8) Alexa Fluor® 488 | sc-393482 AF488 | 200 µg/ml | $364.00 | |||
CSN8 Antibody (F-8) Alexa Fluor® 546 | sc-393482 AF546 | 200 µg/ml | $364.00 | |||
CSN8 Antibody (F-8) Alexa Fluor® 594 | sc-393482 AF594 | 200 µg/ml | $364.00 | |||
CSN8 Antibody (F-8) Alexa Fluor® 647 | sc-393482 AF647 | 200 µg/ml | $364.00 | |||
CSN8 Antibody (F-8) Alexa Fluor® 680 | sc-393482 AF680 | 200 µg/ml | $364.00 | |||
CSN8 Antibody (F-8) Alexa Fluor® 790 | sc-393482 AF790 | 200 µg/ml | $364.00 |