CSN6 Antibody (H-3): sc-137122
- CSN6 Antibody (H-3) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 231-268 near the C-terminus of CSN6 of human origin
- recommended for detection of CSN6 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CSN6 Antibody (H-3) for WB applications. These reagents are now offered in bundles with CSN6 Antibody (H-3) (see ordering information below).
QUICK LINKS
CSN6 Antibody (H-3) is a mouse monoclonal IgG2b light chain antibody that detects CSN6 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CSN6 is a crucial component of the COP9 signalosome complex, which plays a significant role in regulating various developmental and cellular processes. This complex is composed of several proteins, including CSN1, CSN2, CSN3, CSN4, CSN5, CSN6, CSN7a, CSN7b, and CSN8, and is essential for mediating the deneddylation of SCF-type E3 ligase complexes, thereby influencing the ubiquitin conjugation pathway. CSN6 involvement extends to the phosphorylation of key proteins such as p53, c-Jun, IκBα, and IRF-8, which are vital for cellular responses to stress and regulation of the cell cycle. Notably, the phosphorylation of p53 and c-Jun by the COP9 signalosome not only protects these proteins from degradation but also enhances their functional roles in tumor suppression and cellular signaling. CSN6 modulation of these pathways underscores CSN6′s significance in maintaining cellular homeostasis and potential implications in cancer biology and therapeutic interventions.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CSN6 Antibody (H-3) | sc-137122 | 200 µg/ml | $322.00 | |||
CSN6 Antibody (H-3): m-IgG Fc BP-HRP Bundle | sc-537405 | 200 µg Ab; 10 µg BP | $361.00 | |||
CSN6 Antibody (H-3): m-IgGκ BP-HRP Bundle | sc-534660 | 200 µg Ab; 40 µg BP | $361.00 | |||
CSN6 Antibody (H-3): m-IgG2b BP-HRP Bundle | sc-549870 | 200 µg Ab; 10 µg BP | $361.00 | |||
CSN6 (H-3) Neutralizing Peptide | sc-137122 P | 100 µg/0.5 ml | $69.00 |