CSN6 Antibody (B-1): sc-393023

CSN6 Antibody (B-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects CSN6 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). CSN6 (B-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CSN6 functions as a crucial component of the COP9 signalosome (CSN) complex, which plays a significant role in regulating the ubiquitin-proteasome pathway, a vital mechanism for protein degradation and cellular regulation. The CSN complex, composed of several proteins including CSN1, CSN2, CSN3, CSN4, CSN5, CSN6, CSN7a, CSN7b, and CSN8, is essential for various developmental and cellular processes. CSN6 participates in the deneddylation of SCF-type E3 ligase complexes, reducing ubiquitin ligase activity and influencing protein stability and turnover. CSN6 also contributes to the phosphorylation of key regulatory proteins such as p53 and c-Jun, which are critical for cell cycle control and apoptosis. Understanding CSN6 function and interactions within the CSN complex helps elucidate cellular regulation mechanisms and potential implications in various diseases, including cancer.

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CSN6 Antibody (B-1) References:

1. COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system.  |  Bech-Otschir, D., et al. 2001. EMBO J. 20: 1630-9. PMID: 11285227
2. Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome.  |  Hoareau Alves, K., et al. 2002. FEBS Lett. 527: 15-21. PMID: 12220626
3. Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome.  |  Uhle, S., et al. 2003. EMBO J. 22: 1302-12. PMID: 12628923
4. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.  |  Groisman, R., et al. 2003. Cell. 113: 357-67. PMID: 12732143
5. Growth suppression induced by the TRC8 hereditary kidney cancer gene is dependent upon JAB1/CSN5.  |  Gemmill, RM., et al. 2005. Oncogene. 24: 3503-11. PMID: 15735686
6. Binding of JAB1/CSN5 to MIF is mediated by the MPN domain but is independent of the JAMM motif.  |  Burger-Kentischer, A., et al. 2005. FEBS Lett. 579: 1693-701. PMID: 15757663
7. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits.  |  Seeger, M., et al. 1998. FASEB J. 12: 469-78. PMID: 9535219

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CSN6 Antibody (B-1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CSN6 Antibody (B-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CSN6 Antibody (B-1) Specifications

Alternate Product Name: COPS6

Product Clone Name: B-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 28-327

Epitope Target: CSN6

Epitope Species: human

Product Reactivity/Detection: CSN6

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CSN6 Antibody (B-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin