CPSF4 Antibody (D-1): sc-390516
- CPSF4 Antibody (D-1) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-102 mapping at the N-terminus of CPSF4 of human origin
- recommended for detection of CPSF4 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CPSF4 Antibody (D-1) for WB applications. These reagents are now offered in bundles with CPSF4 Antibody (D-1) (see ordering information below).
CPSF4 Antibody (D-1) is a mouse monoclonal IgG2b antibody that detects CPSF4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CPSF4, also known as Cleavage and polyadenylation specificity factor subunit 4, is a crucial nuclear protein that is part of the CPSF complex, which is essential for the proper processing of pre-mRNA, particularly in the formation of the 3′ end. This protein contains five C3H1-type zinc fingers and one CCHC-type zinc finger, which are important for structural integrity and function. The CPSF complex, composed of multiple subunits, recognizes the AAUAAA signal in pre-mRNA, facilitating RNA cleavage and poly(A) tail synthesis. The interaction of CPSF4 with other proteins, such as the suppressor of forked subunit of the cleavage stimulatory factor and poly(A) polymerase, underscores its role in enhancing the efficiency of polyadenylation. Additionally, CPSF4′s interaction with the U1 snRNP-A protein stabilizes binding to AAUAAA-containing RNAs, further promoting effective polyadenylation. The precise regulation of this process is vital for gene expression and the stability of mRNA, making CPSF4 a significant player in post-transcriptional regulation. anti-CPSF4 antibody (D-1) is an invaluable tool for researchers studying RNA processing and its implications in various biological processes and diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CPSF4 Antibody (D-1) | sc-390516 | 200 µg/ml | $316.00 | |||
CPSF4 Antibody (D-1): m-IgG Fc BP-HRP Bundle | sc-538086 | 200 µg Ab; 10 µg BP | $354.00 | |||
CPSF4 Antibody (D-1): m-IgGκ BP-HRP Bundle | sc-535623 | 200 µg Ab; 40 µg BP | $354.00 |