COL5A1 Antibody (H-12): sc-133162

COL5A1 Antibody (H-12) is a mouse monoclonal IgG1 antibody that detects COL5A1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). COL5A1, a member of the collagen family, plays a crucial role in the formation of type V collagen, which is essential for the structural integrity of various tissues, including skin, tendons, and blood vessels. COL5A1 is primarily located in the extracellular matrix, where COL5A1 contributes to the assembly and organization of collagen fibrils, thereby influencing tissue elasticity and strength. Proper functioning of COL5A1 is vital for maintaining normal tissue architecture, and any mutations or deficiencies in COL5A1 can lead to connective tissue disorders, such as Ehlers-Danlos syndrome. Anti-COL5A1 antibody (H-12) is an invaluable tool for researchers studying collagen-related pathologies and the intricate dynamics of extracellular matrix composition and function.

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COL5A1 Antibody (H-12) References:

1. Human fibroblasts with mutations in COL5A1 and COL3A1 genes do not organize collagens and fibronectin in the extracellular matrix, down-regulate alpha2beta1 integrin, and recruit alphavbeta3 Instead of alpha5beta1 integrin.  |  Zoppi, N., et al. 2004. J Biol Chem. 279: 18157-68. PMID: 14970208
2. Structural abnormalities of the cornea and lid resulting from collagen V mutations.  |  Segev, F., et al. 2006. Invest Ophthalmol Vis Sci. 47: 565-73. PMID: 16431952
3. Differential global and extra-cellular matrix focused gene expression patterns between normal and glaucomatous human lamina cribrosa cells.  |  Kirwan, RP., et al. 2009. Mol Vis. 15: 76-88. PMID: 19145252
4. Hypoxia-inducible factor-1 {alpha} expression predicts superior survival in patients with diffuse large B-cell lymphoma treated with R-CHOP.  |  Evens, AM., et al. 2010. J Clin Oncol. 28: 1017-24. PMID: 20048181
5. Insights in the etiopathology of galactosyltransferase II (GalT-II) deficiency from transcriptome-wide expression profiling of skin fibroblasts of two sisters with compound heterozygosity for two novel B3GALT6 mutations.  |  Ritelli, M., et al. 2015. Mol Genet Metab Rep. 2: 1-15. PMID: 28649518
6. Collagen remodelling and plasma ascorbic acid levels in patients suspected of inherited bleeding disorders harbouring germline variants in collagen-related genes.  |  Fager Ferrari, M., et al. 2021. Haemophilia. 27: e69-e77. PMID: 33161638
7. NAT10 promotes gastric cancer metastasis via N4-acetylated COL5A1.  |  Zhang, Y., et al. 2021. Signal Transduct Target Ther. 6: 173. PMID: 33941767
8. Collagen family genes and related genes might be associated with prognosis of patients with gastric cancer: an integrated bioinformatics analysis and experimental validation.  |  Weng, K., et al. 2020. Transl Cancer Res. 9: 6246-6262. PMID: 35117235
9. Identification of key genes in colorectal cancer diagnosis by co-expression analysis weighted gene co-expression network analysis.  |  Mortezapour, M., et al. 2023. Comput Biol Med. 157: 106779. PMID: 36931200
10. COL5A1 promotes triple-negative breast cancer progression by activating tumor cell-macrophage crosstalk.  |  Chen, X., et al. 2024. Oncogene. 43: 1742-1756. PMID: 38609499

The preferred COL5A1 antibody is COL5A1 Antibody (C-5): sc-166155.