CEACAM1 Antibody (E-1): sc-166453

CEACAM1 Antibody (E-1) is a mouse monoclonal IgG2b kappa light chain antibody that detects CEACAM1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). anti-CEACAM1 antibody (E-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CEACAM1, also known as carcinoembryonic antigen-related cell adhesion molecule 1, is a 526 amino acid protein that plays a crucial role in cell adhesion and signaling processes. CEACAM1 (E-1) monoclonal antibody is particularly important due to involvement in the modulation of immune responses and potential role in tumor suppression, as CEACAM1 is underexpressed in colorectal cancers. CEACAM1 exists in several alternatively spliced isoforms, some membrane-bound while others secreted, allowing for diverse functional roles in different cellular contexts. CEACAM1 contains one immunoglobulin-like V-type domain and three C2-type domains, which contribute to structural integrity and functional versatility. CEACAM1′s ability to interact with various ligands and other proteins underscores significance in cellular communication and maintenance of tissue architecture, making anti-CEACAM1 antibody (E-1) an essential tool for researchers studying cancer biology and immune regulation.

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CEACAM1 Antibody (E-1) References:

1. The CEACAM1 transmembrane domain, but not the cytoplasmic domain, directs internalization of human pathogens via membrane microdomains.  |  Muenzner, P., et al. 2008. Cell Microbiol. 10: 1074-92. PMID: 18081725
2. The CEACAM1-mediated apoptosis pathway is activated by CEA and triggers dual cleavage of CEACAM1.  |  Nittka, S., et al. 2008. Oncogene. 27: 3721-8. PMID: 18278069
3. CEACAM1 dynamics during neisseria gonorrhoeae suppression of CD4+ T lymphocyte activation.  |  Lee, HS., et al. 2008. J Immunol. 180: 6827-35. PMID: 18453603
4. Altered splicing of CEACAM1 in breast cancer: identification of regulatory sequences that control splicing of CEACAM1 into long or short cytoplasmic domain isoforms.  |  Gaur, S., et al. 2008. Mol Cancer. 7: 46. PMID: 18507857
5. CEACAM1, a SOX9 direct transcriptional target identified in the colon epithelium.  |  Zalzali, H., et al. 2008. Oncogene. 27: 7131-8. PMID: 18794798
6. CEACAM1 inhibits Toll-like receptor 2-triggered antibacterial responses of human pulmonary epithelial cells.  |  Slevogt, H., et al. 2008. Nat Immunol. 9: 1270-8. PMID: 18836450
7. Cytokine-induced CEACAM1 expression on keratinocytes is characteristic for psoriatic skin and contributes to a prolonged lifespan of neutrophils.  |  Rahmoun, M., et al. 2009. J Invest Dermatol. 129: 671-81. PMID: 18843289
8. Interdependency of CEACAM-1, -3, -6, and -8 induced human neutrophil adhesion to endothelial cells.  |  Skubitz, KM. and Skubitz, AP. 2008. J Transl Med. 6: 78. PMID: 19077207
9. CEACAM1: a key regulator of vascular permeability.  |  Nouvion, AL., et al. 2010. J Cell Sci. 123: 4221-30. PMID: 21081647
10. CEACAM1 deficiency delays important wound healing processes.  |  LeBlanc, S., et al. 2011. Wound Repair Regen. 19: 745-52. PMID: 22092845
11. CEACAM1 Is Associated With the Suppression of Natural Killer Cell Function in Patients With Chronic Hepatitis C.  |  Suda, T., et al. 2018. Hepatol Commun. 2: 1247-1258. PMID: 30288478
12. CEACAM1 regulates the IL-6 mediated fever response to LPS through the RP105 receptor in murine monocytes.  |  Zhang, Z., et al. 2019. BMC Immunol. 20: 7. PMID: 30674283

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CEACAM1 Antibody (E-1) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-CEACAM1 Antibody (E-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CEACAM1 Antibody (E-1) Specifications

Alternate Product Name: CEACAM1

Product Clone Name: E-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 391-526

Epitope Target: CEACAM1

Epitope Species: human

Product Reactivity/Detection: CEACAM1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for CEACAM1 Antibody (E-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred CEACAM1/2 antibody is CEACAM1/2 Antibody (E-12): sc-365126.