Cdc16 Antibody (D-1): sc-376091
- Cdc16 Antibody (D-1) is a mouse monoclonal IgG2b κ Cdc16 antibody provided at 200 µg/ml
- raised against amino acids 269-568 mapping at the C-terminus of Cdc16 of human origin
- Cdc16 Antibody (D-1) is recommended for detection of Cdc16 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Cdc16 Antibody (D-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for Cdc16 Antibody (D-1) for WB and IHC(P) applications. These reagents are now offered in bundles with Cdc16 Antibody (D-1) (see ordering information below).
Cdc16 Antibody (D-1) is a mouse monoclonal IgG2b kappa light chain antibody that detects Cdc16 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-Cdc16 antibody (D-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cdc16 (D-1) antibody recognizes a protein that plays a crucial role in cell cycle regulation, particularly as a component of the anaphase-promoting complex (APC), which is essential for ubiquitination and subsequent degradation of cyclin B. This degradation ensures proper transition from metaphase to anaphase during cell division, enabling accurate chromosome segregation. Dysregulation of Cdc16 and APC can lead to abnormal cell cycle progression and has been linked to various cancers, making Cdc16 research valuable for understanding basic cellular processes and developing potential therapeutic strategies. Cdc16 (D-1) monoclonal antibody helps study interactions with other proteins, such as Cdc27, highlighting the significance of Cdc16 in the ubiquitin-proteasome pathway and its role in maintaining cellular homeostasis and cell cycle integrity.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Cdc16 Antibody (D-1) References:
- Identification of genes with correlated patterns of variations in DNA copy number and gene expression level in gastric cancer. | Yang, S., et al. 2007. Genomics. 89: 451-9. PMID: 17229543
- Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene. | Westlake, CJ., et al. 2007. Proc Natl Acad Sci U S A. 104: 1236-41. PMID: 17229837
- cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. | Gautier, J., et al. 1991. Cell. 67: 197-211. PMID: 1913817
- Mitotic transmission of artificial chromosomes in cdc mutants of the yeast, Saccharomyces cerevisiae. | Palmer, RE., et al. 1990. Genetics. 125: 763-74. PMID: 2204582
- A new twist to the cell cycle. | Barinaga, M. 1995. Science. 269: 631-2. PMID: 7624789
- A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. | King, RW., et al. 1995. Cell. 81: 279-88. PMID: 7736580
- Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast. | Plon, SE., et al. 1993. Proc Natl Acad Sci U S A. 90: 10484-8. PMID: 8248134
- Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4. | Stepanova, L., et al. 1996. Genes Dev. 10: 1491-502. PMID: 8666233
- A human protein related to yeast Cdc6p. | Williams, RS., et al. 1997. Proc Natl Acad Sci U S A. 94: 142-7. PMID: 8990175
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cdc16 Antibody (D-1) | sc-376091 | 200 µg/ml | $322.00 | |||
Cdc16 Antibody (D-1): m-IgG Fc BP-HRP Bundle | sc-525995 | 200 µg Ab; 10 µg BP | $361.00 | |||
Cdc16 Antibody (D-1): m-IgG2b BP-HRP Bundle | sc-549659 | 200 µg Ab; 10 µg BP | $361.00 | |||
Cdc16 Antibody (D-1) AC | sc-376091 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Cdc16 Antibody (D-1) HRP | sc-376091 HRP | 200 µg/ml | $322.00 | |||
Cdc16 Antibody (D-1) FITC | sc-376091 FITC | 200 µg/ml | $336.00 | |||
Cdc16 Antibody (D-1) PE | sc-376091 PE | 200 µg/ml | $349.00 | |||
Cdc16 Antibody (D-1) Alexa Fluor® 488 | sc-376091 AF488 | 200 µg/ml | $364.00 | |||
Cdc16 Antibody (D-1) Alexa Fluor® 546 | sc-376091 AF546 | 200 µg/ml | $364.00 | |||
Cdc16 Antibody (D-1) Alexa Fluor® 594 | sc-376091 AF594 | 200 µg/ml | $364.00 | |||
Cdc16 Antibody (D-1) Alexa Fluor® 647 | sc-376091 AF647 | 200 µg/ml | $364.00 | |||
Cdc16 Antibody (D-1) Alexa Fluor® 680 | sc-376091 AF680 | 200 µg/ml | $364.00 | |||
Cdc16 Antibody (D-1) Alexa Fluor® 790 | sc-376091 AF790 | 200 µg/ml | $364.00 |