Cdc16 Activators
Cdc16 Activators are a class of chemical compounds that function to enhance the activity of the Cdc16 protein. Cdc16 is a core component of the anaphase-promoting complex/cyclosome(APC/C), a multi-subunit E3 ubiquitin ligase that targets specific cell-cycle proteins for degradation by the 26S proteasome, thereby controlling progression through the cell cycle. The activity of Cdc16 can be enhanced by the action of several chemical compounds that influence various biochemical pathways. Wortmannin and LY294002, for example, are potent inhibitors of phosphatidylinositol 3-kinase (PI3K). By inhibiting PI3K, these compounds prevent the downstream activation of AKT, which in turn increases the activity of GSK3β, a regulator of cell cycle progression. The increased activity of GSK3β can enhance the functional activity of Cdc16.
Other compounds such as SB216763, a potent inhibitor of GSK3, and Y-27632, an inhibitor of ROCK family kinases, can enhance the activity of Cdc16 by modifying cytoskeletal dynamics. Similarly, PD98059, a selective inhibitor of MEK1 activation and the MAPK cascade, can increase the activity of GSK3β, which in turn enhances Cdc16 function. Inhibitors of protein kinase A (PKA) such as H-89, and p38 MAPK inhibitors like SB203580, can also modulate cell cycle progression and enhance the functional activity of Cdc16. Other inhibitors, including U0126 (a selective inhibitor of MEK1 and MEK2), SP600125 (a potent inhibitor of JNK), KN-93 (an inhibitor of CaMKII), Gö6983 (an inhibitor of PKC), and SU6656 (a selective Src family kinase inhibitor), can also enhance the functional activity of Cdc16 by modulating cell cycle progression.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent, irreversible inhibitor of phosphatidylinositol 3-kinase. By inhibiting PI3K, it prevents the downstream activation of AKT, which in turn increases the activity of GSK3β. GSK3β is involved in the regulation of cell cycle progression, and its activation can enhance the functional activity of Cdc16. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a morpholine derivative and a potent inhibitor of phosphatidylinositol 3-kinase (PI3K). It prevents the downstream activation of AKT, thus increasing GSK3β activity, a regulator of cell cycle progression. This can enhance the functional activity of Cdc16. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $70.00 $198.00 | 18 | |
SB-216763 is a potent and selective inhibitor of GSK3. Its inhibitory action on GSK3β can indirectly increase the activity of Cdc16, as GSK3β is known to regulate cell cycle progression. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a potent and selective inhibitor of ROCK family kinases. By inhibiting ROCK, it can modify cytoskeletal dynamics and thus potentially enhance the functional activity of Cdc16, which is involved in cell cycle regulation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is a selective inhibitor of MEK1 activation and the MAPK cascade. Inhibition of this pathway can increase the activity of GSK3β, which in turn enhances the functional activity of Cdc16. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB 203580 is a specific inhibitor of p38 MAPK. By inhibiting p38 MAPK, it can modulate cell cycle progression and potentially enhance the functional activity of Cdc16. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 is a potent, selective, and reversible inhibitor of JNK. By inhibiting JNK, it can modulate cell cycle progression and potentially enhance the functional activity of Cdc16. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93 is a potent inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII). By inhibiting CaMKII, it can modulate cell cycle progression and potentially enhance the functional activity of Cdc16. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Gö 6983 is a potent and selective inhibitor of PKC. By inhibiting PKC, it can modulate cell cycle progression and potentially enhance the functional activity of Cdc16. | ||||||
SU6656 | 330161-87-0 | sc-203286 sc-203286A | 1 mg 5 mg | $56.00 $130.00 | 27 | |
SU6656 is a selective Src family kinase inhibitor. By inhibiting Src kinases, it can modulate cell cycle progression and potentially enhance the functional activity of Cdc16. | ||||||