CD71/TFRC/Transferrin Receptor Antibody (G-8): sc-393719

CD71 Antibody (G-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects CD71 protein from mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CD71 (G-8) antibody is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CD71, also known as transferrin receptor (TFR), is a type II membrane glycoprotein forming a disulfide-linked homodimer of two identical subunits. CD71 maintains iron homeostasis by binding to transferrin, a serum iron-transport protein, and facilitates cellular iron uptake through receptor-mediated endocytosis. CD71 expression remains high in proliferating cells, reticulocytes, and erythroid precursors, while staying absent in resting leukocytes but becoming upregulated upon activation of lymphocytes, monocytes, and macrophages. CD71 appears on most dividing cells and brain endothelium, showing significance in hematopoiesis and neurobiology. A second transferrin receptor, TFR2, mediates transferrin-bound iron uptake and appears predominantly in liver, hepatocytes, and erythroid precursors. TFR2 gene mutations lead to hereditary hemochromatosis type III (HFE3), an iron overload disorder primarily affecting Caucasians, highlighting CD71′s importance in iron metabolism and related pathologies.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD71/TFRC/Transferrin Receptor Antibody (G-8) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-CD71/TFRC/Transferrin Receptor Antibody (G-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD71/TFRC/Transferrin Receptor Antibody (G-8) Specifications

Alternate Product Name: CD71

Product Clone Name: G-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 708-737

Epitope Target: CD71

Epitope Species: human

Product Reactivity/Detection: CD71

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for CD71/TFRC/Transferrin Receptor Antibody (G-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred CD71/TFRC/Transferrin Receptor antibody is CD71/TFRC/Transferrin Receptor Antibody (3B8 2A1): sc-32272.