CD71/TFRC/Transferrin Receptor Antibody (DF1513): sc-7327
- CD71/TFRC/Transferrin Receptor Antibody (DF1513) is a mouse monoclonal IgG1 κ, cited in 19 publications, provided at 200 µg/ml
- raised against KG1 acute myeloid leukemia cell line
- recommended for detection of CD71 of human origin by IF, IHC(P) and FCM
- available conjugated to either phycoerythrin, FITC, Alexa Fluor® 488 or Alexa Fluor® 647 for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 405 for IF, IHC(P) and FCM
- See CD71/TFRC/Transferrin Receptor (3B8 2A1): sc-32272 for CD71/TFRC/Transferrin Receptor antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD71/TFRC/Transferrin Receptor Antibody (DF1513) for IHC(P) applications. These reagents are now offered in bundles with CD71/TFRC/Transferrin Receptor Antibody (DF1513) (see ordering information below).
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SEE ALSO...
CD71 Antibody (DF1513) is a mouse monoclonal IgG1 antibody that detects CD71 in human samples through applications such as immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). CD71, also known as the transferrin receptor (TFR), is a type II membrane glycoprotein that forms a disulfide-linked homodimer, consisting of two identical subunits. Anti-CD71 antibody (DF1513) plays a crucial role in studying iron homeostasis, where CD71 binds to transferrin, a serum iron-transport protein, and facilitates cellular uptake of iron via receptor-mediated endocytosis. CD71 expression is typically high in proliferating cells, reticulocytes, and erythroid precursors, while remaining absent in resting leukocytes but can be upregulated upon activation of lymphocytes, monocytes, and macrophages. CD71 is also present on most dividing cells and brain endothelium, highlighting its importance in various physiological processes. The interaction of CD71 with transferrin is vital for maintaining iron levels in the body, as iron is essential for numerous cellular functions, including oxygen transport and DNA synthesis. Additionally, mutations in the TFR2 gene, which encodes a second transferrin receptor, can lead to hereditary hemochromatosis type III, an iron overload disorder, underscoring the significance of CD71 in both health and disease. CD71 monoclonal antibody (DF1513) serves as an invaluable tool for researchers studying iron metabolism and related disorders.
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD71/TFRC/Transferrin Receptor Antibody (DF1513) | sc-7327 | 200 µg/ml | $322.00 | |||
CD71/TFRC/Transferrin Receptor Antibody (DF1513): m-IgG Fc BP-HRP Bundle | sc-536557 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD71/TFRC/Transferrin Receptor Antibody (DF1513): m-IgGκ BP-HRP Bundle | sc-533708 | 200 µg Ab; 40 µg BP | $361.00 | |||
CD71/TFRC/Transferrin Receptor Antibody (DF1513): m-IgG1 BP-HRP Bundle | sc-544673 | 200 µg Ab; 20 µg BP | $361.00 | |||
CD71/TFRC/Transferrin Receptor Antibody (DF1513) Alexa Fluor® 405 | sc-7327 AF405 | 200 µg/ml | $364.00 | |||
CD71/TFRC/Transferrin Receptor Antibody (DF1513) Alexa Fluor® 488 | sc-7327 AF488 | 200 µg/ml | $364.00 | |||
CD71/TFRC/Transferrin Receptor Antibody (DF1513) Alexa Fluor® 647 | sc-7327 AF647 | 200 µg/ml | $364.00 | |||
CD71/TFRC/Transferrin Receptor Antibody (DF1513) FITC | sc-7327 FITC | 200 µg/ml | $336.00 | |||
CD71/TFRC/Transferrin Receptor Antibody (DF1513) PE | sc-7327 PE | 200 µg/ml | $349.00 |