CD71/TFRC/Transferrin Receptor Antibody (DF1513): sc-7327

CD71 Antibody (DF1513) is a mouse monoclonal IgG1 antibody that detects CD71 in human samples through applications such as immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). CD71, also known as the transferrin receptor (TFR), is a type II membrane glycoprotein that forms a disulfide-linked homodimer, consisting of two identical subunits. Anti-CD71 antibody (DF1513) plays a crucial role in studying iron homeostasis, where CD71 binds to transferrin, a serum iron-transport protein, and facilitates cellular uptake of iron via receptor-mediated endocytosis. CD71 expression is typically high in proliferating cells, reticulocytes, and erythroid precursors, while remaining absent in resting leukocytes but can be upregulated upon activation of lymphocytes, monocytes, and macrophages. CD71 is also present on most dividing cells and brain endothelium, highlighting its importance in various physiological processes. The interaction of CD71 with transferrin is vital for maintaining iron levels in the body, as iron is essential for numerous cellular functions, including oxygen transport and DNA synthesis. Additionally, mutations in the TFR2 gene, which encodes a second transferrin receptor, can lead to hereditary hemochromatosis type III, an iron overload disorder, underscoring the significance of CD71 in both health and disease. CD71 monoclonal antibody (DF1513) serves as an invaluable tool for researchers studying iron metabolism and related disorders.

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CD71/TFRC/Transferrin Receptor Antibody (DF1513) References:

1. Immunosuppressive CD71+ erythroid cells compromise neonatal host defence against infection.  |  Elahi, S., et al. 2013. Nature. 504: 158-62. PMID: 24196717
2. Correlation of transferrin receptor (CD71) with Ki67 expression on stimulated human and mouse T cells: The kinetics of expression of T cell activation markers.  |  Motamedi, M., et al. 2016. J Immunol Methods. 437: 43-52. PMID: 27555239
3. The unhealthy attraction of Plasmodium vivax to reticulocytes expressing transferrin receptor 1 (CD71).  |  Malleret, B., et al. 2017. Int J Parasitol. 47: 379-383. PMID: 28414070
4. CD71 mesangial IgA1 receptor and the progression of IgA nephropathy.  |  Jhee, JH., et al. 2021. Transl Res. 230: 34-43. PMID: 33122053
5. The role of CD71+ erythroid cells in the regulation of the immune response.  |  Grzywa, TM., et al. 2021. Pharmacol Ther. 228: 107927. PMID: 34171326
6. Cultured CD71+ erythroid cells modulate the host immune response.  |  Alshalani, A., et al. 2023. Transfus Med. 33: 257-262. PMID: 36919690
7. CD71+ erythroid cells suppress T-cell effector functions and predict immunotherapy outcomes in patients with virus-associated solid tumors.  |  Bozorgmehr, N., et al. 2023. J Immunother Cancer. 11: PMID: 37236637
8. CD71-mediated liposomal arsenic-nickel complex combined with all-trans retinoic acid for the efficacy of acute promyelocytic leukemia.  |  Liu, X., et al. 2023. Asian J Pharm Sci. 18: 100826. PMID: 37583710
9. Nutrition impact on ILC3 maintenance and function centers on a cell-intrinsic CD71-iron axis.  |  Xiong, L., et al. 2023. Nat Immunol. 24: 1671-1684. PMID: 37709985
10. Anaplastic thyroid cancer cells reduce CD71 levels to increase iron overload tolerance.  |  D'Aprile, S., et al. 2023. J Transl Med. 21: 780. PMID: 37924062

The preferred CD71/TFRC/Transferrin Receptor antibody is CD71/TFRC/Transferrin Receptor Antibody (3B8 2A1): sc-32272.