caspase-7 Antibody (7CSP02): sc-81660

caspase-7 Antibody (7CSP02) is a mouse monoclonal IgG1 antibody that detects caspase-7 in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP) applications. Caspase-7 is a crucial member of the Ced-3/caspase-1 family of cysteine proteases, which are integral to the apoptotic process, facilitating programmed cell death by cleaving specific target proteins that regulate cellular longevity. Notably, caspase-7 cleaves poly(ADP-ribose) polymerase (PARP), a nuclear protein that plays a vital role in DNA repair and cellular stress responses. PARP cleavage by caspase-7 results in the generation of an apoptotic fragment, which is a hallmark of apoptosis and serves as a signal for the cell to undergo programmed death. This process is essential for maintaining tissue homeostasis and preventing the proliferation of damaged cells, thereby playing a significant role in cancer biology and neurodegenerative diseases. Anti-caspase-7 antibody (7CSP02) provides high specificity and sensitivity, making caspase-7 (7CSP02) monoclonal antibody an invaluable tool for researchers studying apoptosis and its implications in various pathological conditions.

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caspase-7 Antibody (7CSP02) References:

1. Caspase 7 downregulation as an immunohistochemical marker of colonic carcinoma.  |  Palmerini, F., et al. 2001. Hum Pathol. 32: 461-7. PMID: 11381362
2. Cleaved caspase-3, caspase-7 and poly (ADP-ribose) polymerase are complementarily but differentially expressed in human medulloblastomas.  |  Puig, B., et al. 2001. Neurosci Lett. 306: 85-8. PMID: 11403964
3. Requirement of caspase-3 for efficient apoptosis induction and caspase-7 activation but not viral replication or cell rounding in cells infected with vesicular stomatitis virus.  |  Hobbs, JA., et al. 2003. Hum Immunol. 64: 82-92. PMID: 12507817
4. Caspase-2 is resistant to inhibition by inhibitor of apoptosis proteins (IAPs) and can activate caspase-7.  |  Ho, PK., et al. 2005. FEBS J. 272: 1401-14. PMID: 15752357
5. Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway.  |  Clarke, CA., et al. 2005. J Biol Chem. 280: 35337-45. PMID: 16123041
6. Influence of co-down-regulation of caspase-3 and caspase-7 by siRNAs on sodium butyrate-induced apoptotic cell death of Chinese hamster ovary cells producing thrombopoietin.  |  Sung, YH., et al. 2007. Metab Eng. 9: 452-64. PMID: 17892962
7. FRET evidence that an isoform of caspase-7 binds but does not cleave its substrate.  |  Li, IT., et al. 2006. Conf Proc IEEE Eng Med Biol Soc. 2006: 531-4. PMID: 17946841
8. Caspase-7 ablation modulates UPR, reprograms TRAF2-JNK apoptosis and protects T17M rhodopsin mice from severe retinal degeneration.  |  Choudhury, S., et al. 2013. Cell Death Dis. 4: e528. PMID: 23470535
9. Targeting the XIAP/caspase-7 complex selectively kills caspase-3-deficient malignancies.  |  Lin, YF., et al. 2013. J Clin Invest. 123: 3861-75. PMID: 23979166
10. Immunohistochemical expression of caspase-3, caspase-5, caspase-7 and apoptotic protease-activating factor-1 (APAF-1) in the liver and kidney of rats exposed to zoledronic acid (ZOL) and basic fibroblast growth factor (bFGF).  |  Aydogan, A., et al. 2014. Vet Q. 34: 137-42. PMID: 24865775

The preferred caspase-7 antibody is caspase-7 Antibody (10-1-62): sc-56063.