caspase-7 Antibody (13.1.97): sc-73424
- caspase-7 Antibody (13.1.97) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against full length caspase-7 of human origin
- recommended for detection of caspase-7 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for caspase-7 Antibody (13.1.97). This work is in progress.
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Caspase-7 Antibody (13.1.97) is a mouse monoclonal IgG1 antibody that detects caspase-7 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Caspase-7 is a crucial member of the Ced-3/caspase-1 family of cysteine proteases, which are integral to the apoptotic process, facilitating programmed cell death by cleaving specific target proteins that are vital for cellular longevity. Notably, caspase-7 cleaves poly(ADP-ribose) polymerase (PARP), a nuclear protein that plays a significant role in DNA repair and cellular stress responses. The cleavage of PARP by caspase-7 results in the generation of an apoptotic fragment, which is a hallmark of apoptosis and serves as a signal for the cell to undergo programmed death. This function underscores caspase-7′s importance in maintaining cellular homeostasis and responding to cellular damage, making anti-caspase-7 antibody (13.1.97) an essential tool for researchers studying the mechanisms of apoptosis and the role of caspases in various biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
caspase-7 Antibody (13.1.97) References:
- Human caspase-7 activity and regulation by its N-terminal peptide. | Denault, JB. and Salvesen, GS. 2003. J Biol Chem. 278: 34042-50. PMID: 12824163
- Mining of caspase-7 substrates using a degradomic approach. | Jang, M., et al. 2008. Mol Cells. 26: 152-7. PMID: 18596415
- Conformational similarity in the activation of caspase-3 and -7 revealed by the unliganded and inhibited structures of caspase-7. | Agniswamy, J., et al. 2009. Apoptosis. 14: 1135-44. PMID: 19655253
- Caspase-7 participates in differentiation of cells forming dental hard tissues. | Matalova, E., et al. 2013. Dev Growth Differ. 55: 615-21. PMID: 23713787
- Apoptotic and nonapoptotic function of caspase 7 in spermatogenesis. | Lei, B., et al. 2017. Asian J Androl. 19: 47-51. PMID: 26643564
- Caspase-1 Deficiency Alleviates Dopaminergic Neuronal Death via Inhibiting Caspase-7/AIF Pathway in MPTP/p Mouse Model of Parkinson's Disease. | Qiao, C., et al. 2017. Mol Neurobiol. 54: 4292-4302. PMID: 27339879
- Dual Site Phosphorylation of Caspase-7 by PAK2 Blocks Apoptotic Activity by Two Distinct Mechanisms. | Eron, SJ., et al. 2017. Structure. 25: 27-39. PMID: 27889207
- Loss of the cone-enriched caspase-7 does not affect secondary cone death in retinitis pigmentosa. | Venkatesh, A., et al. 2017. Mol Vis. 23: 944-951. PMID: 29296074
- Knockout of caspase-7 gene improves the expression of recombinant protein in CHO cell line through the cell cycle arrest in G2/M phase. | Safari, F. and Akbari, B. 2022. Biol Res. 55: 2. PMID: 35016732
- The E3 Ligase TRIM25 Impairs Apoptotic Cell Death in Colon Carcinoma Cells via Destabilization of Caspase-7 mRNA: A Possible Role of hnRNPH1. | Nasrullah, U., et al. 2023. Cells. 12: PMID: 36611995
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
caspase-7 Antibody (13.1.97) | sc-73424 | 200 µg/ml | $322.00 |