caspase-6 Antibody (3F52): sc-56060

Caspase-6 Antibody (3F52) is a mouse monoclonal IgG1 kappa light chain antibody that detects the caspase-6 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-caspase-6 antibody (3F52) is available as a non-conjugated format. Caspase-6 is a member of the Ced-3/caspase-1 family of cysteine proteases, which are crucial for the execution of apoptosis, a programmed cell death process essential for maintaining cellular homeostasis and development. Caspase-6 is primarily located in the cytoplasm and is activated in response to apoptotic signals, where caspase-6 plays a pivotal role in cleaving specific substrates that are vital for cellular integrity. Notably, caspase-6 has been shown to cleave nuclear lamins, which are integral to maintaining the structural integrity of the nuclear envelope and ensuring proper cellular morphology. The precise regulation of caspase-6 activity is critical, as dysregulation can lead to various pathological conditions, including neurodegenerative diseases and cancer. Caspase-6 (3F52) antibody can help researchers gain valuable insights into the mechanisms of apoptosis and the role of caspase-6 in cellular processes.

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caspase-6 Antibody (3F52) References:

1. An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis.  |  Zhao, P., et al. 2020. Science. 367: 652-660. PMID: 32029622
2. Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense.  |  Zheng, M., et al. 2020. Cell. 181: 674-687.e13. PMID: 32298652
3. FGF4 protects the liver from nonalcoholic fatty liver disease by activating the AMP-activated protein kinase-Caspase 6 signal axis.  |  Song, L., et al. 2022. Hepatology. 76: 1105-1120. PMID: 35152446
4. Caspase-6 is a key regulator of cross-talk signal way in PANoptosis in cancer.  |  Qi, L., et al. 2023. Immunology. 169: 245-259. PMID: 36814103
5. Caspase 6/NR4A1/SOX9 signaling axis regulates hepatic inflammation and pyroptosis in ischemia-stressed fatty liver.  |  Sheng, M., et al. 2023. Cell Death Discov. 9: 106. PMID: 36977670
6. Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks.  |  Lindahl, T., et al. 1995. Trends Biochem Sci. 20: 405-11. PMID: 8533153
7. ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis.  |  Duan, H., et al. 1996. J Biol Chem. 271: 1621-5. PMID: 8576161
8. Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death.  |  Casciola-Rosen, L., et al. 1996. J Exp Med. 183: 1957-64. PMID: 8642305
9. ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.  |  Duan, H., et al. 1996. J Biol Chem. 271: 16720-4. PMID: 8663294
10. Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.  |  Takahashi, A., et al. 1996. Proc Natl Acad Sci U S A. 93: 8395-400. PMID: 8710882
11. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.  |  Fernandes-Alnemri, T., et al. 1996. Proc Natl Acad Sci U S A. 93: 7464-9. PMID: 8755496
12. The expression of poly(ADP-ribose) polymerase during differentiation-linked DNA replication reveals that it is a component of the multiprotein DNA replication complex.  |  Simbulan-Rosenthal, CM., et al. 1996. Biochemistry. 35: 11622-33. PMID: 8794742

The preferred caspase-6 p10 antibody is caspase-6 p10 Antibody (H-12): sc-377393.