caspase-14 Antibody (C-12): sc-48395

Caspase-14 Antibody (C-12) is a mouse monoclonal IgG2a antibody that detects caspase-14 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Caspase-14 is a unique member of the Ced-3/caspase family, which plays a crucial role in the apoptotic process by selectively cleaving specific target proteins that are vital for cellular longevity. Notably, caspase-14 is highly expressed in embryonic tissues, indicating its importance during development, but is largely absent in adult tissues, suggesting a specialized function in early life stages. Caspase-14 can be processed in vitro by caspase-8 and caspase-10, highlighting potential interactions within the apoptotic signaling pathways. The ability of caspase-14 to generate apoptotic fragments underscores its significance in regulating cell death and maintaining tissue homeostasis. Anti-caspase-14 antibody (C-12) is an essential tool for researchers studying apoptosis and its implications in various diseases, including cancer and neurodegenerative disorders.

The preferred caspase-14 antibody is caspase-14 Antibody (D-10): sc-48336.