caspase-11 p20 Antibody (A-2): sc-374615

caspase-11 p20 Antibody (A-2) is a mouse monoclonal IgG1 kappa light chain antibody raised against amino acids 141-195 of caspase-11 of mouse origin, exhibiting reactivity with mouse and rat species. Caspase-11 is a crucial inflammatory caspase in mice that plays a significant role in the innate immune response, particularly in the detection of intracellular lipopolysaccharides (LPS) from Gram-negative bacteria. Upon recognition of LPS, caspase-11 becomes activated and induces pyroptosis, a form of programmed cell death characterized by cell swelling and lysis, leading to the release of pro-inflammatory cytokines like interleukin-1β (IL-1β). This process is essential for controlling bacterial infections but can contribute to pathological inflammation if unregulated. Caspase-11 also influences the synthesis of functional cytokines and has been implicated in neuroinflammatory conditions such as experimental autoimmune encephalomyelitis (EAE). Understanding the function of caspase-11 is important for insights into sepsis, neurodegenerative diseases, and other inflammatory disorders. Anti-caspase-11 antibody (A-2) is suitable for applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), enzyme-linked immunosorbent assay (ELISA), and immunohistochemistry, making this tool valuable for researchers investigating the mechanisms of inflammation, cell death, and immune responses mediated by caspase-11.

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caspase-11 p20 Antibody (A-2) References:

1. The most unkindest cut of all: on the multiple roles of mammalian caspases.  |  Fadeel, B., et al. 2000. Leukemia. 14: 1514-25. PMID: 10942252
2. Noncaspase proteases in apoptosis.  |  Johnson, DE. 2000. Leukemia. 14: 1695-703. PMID: 10995018
3. Caspase pathways, neuronal apoptosis, and CNS injury.  |  Eldadah, BA. and Faden, AI. 2000. J Neurotrauma. 17: 811-29. PMID: 11063050
4. Proteases for cell suicide: functions and regulation of caspases.  |  Chang, HY. and Yang, X. 2000. Microbiol Mol Biol Rev. 64: 821-46. PMID: 11104820
5. Caspases: key players in programmed cell death.  |  Grütter, MG. 2000. Curr Opin Struct Biol. 10: 649-55. PMID: 11114501
6. Signaling for the caspases: their role in prostate cell apoptosis.  |  Coffey, RN., et al. 2001. J Urol. 165: 5-14. PMID: 11125352
7. Caspase-11 mediates oligodendrocyte cell death and pathogenesis of autoimmune-mediated demyelination.  |  Hisahara, S., et al. 2001. J Exp Med. 193: 111-22. PMID: 11136825
8. Caspase mRNA expression in a rat model of focal cerebral ischemia.  |  Harrison, DC., et al. 2001. Brain Res Mol Brain Res. 89: 133-46. PMID: 11311984

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-caspase-11 p20 Antibody (A-2) has 23 citations in a variety of scientific publications.

Primary antibodies like Anti-caspase-11 p20 Antibody (A-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

caspase-11 p20 Antibody (A-2) Specifications

Alternate Product Name: caspase-11 p20

Product Clone Name: A-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 141-195

Epitope Target: caspase-11

Epitope Species: mouse

Product Reactivity/Detection: caspase-11

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 23 citations in various scientific publications

Available Conjugates/Forms for caspase-11 p20 Antibody (A-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin