BTG2 Antibody (1A5): sc-517187

BTG2 Antibody (1A5) is a mouse monoclonal IgG1 kappa light chain antibody that detects BTG2 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-BTG2 antibody (1A5) is available as the non-conjugated monoclonal isotype antibody. BTG2 is a crucial member of the B cell translocation gene family, which plays a significant role in regulating cell proliferation and transcription. BTG2 functions as a p53-inducible protein that acts as an anti-proliferative factor, particularly influencing the G1/S transition of the cell cycle. BTG2 expression increases in response to various cellular stressors, including DNA damage and growth stimulation, highlighting BTG2′s importance in maintaining cellular integrity and regulating the cell cycle. High levels of BTG2 are found in key tissues such as kidney proximal tubules, lung alveolar bronchial epithelium, and the basal cell layer of prostate acini, indicating BTG2′s vital role in these organs. BTG2 contains LXXLL motifs, which are essential for interaction with nuclear receptors, further underscoring BTG2′s involvement in transcriptional regulation. BTG2′s ability to modulate cell cycle progression and respond to cellular signals makes BTG2 a significant protein in cancer research and therapeutic development.

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BTG2 Antibody (1A5) References:

1. Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway.  |  Prévôt, D., et al. 2001. J Biol Chem. 276: 9640-8. PMID: 11136725
2. The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair?  |  Tirone, F. 2001. J Cell Physiol. 187: 155-65. PMID: 11267995
3. The human BTG2/TIS21/PC3 gene: genomic structure, transcriptional regulation and evaluation as a candidate tumor suppressor gene.  |  Duriez, C., et al. 2002. Gene. 282: 207-14. PMID: 11814693
4. Expression of B-cell translocation gene 2 protein in normal human tissues.  |  Melamed, J., et al. 2002. Tissue Cell. 34: 28-32. PMID: 11989967
5. BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms.  |  Morel, AP., et al. 2003. J Cell Sci. 116: 2929-36. PMID: 12771185
6. BTG1, a member of a new family of antiproliferative genes.  |  Rouault, JP., et al. 1992. EMBO J. 11: 1663-70. PMID: 1373383
7. Impaired expression of the cell cycle regulator BTG2 is common in clear cell renal cell carcinoma.  |  Struckmann, K., et al. 2004. Cancer Res. 64: 1632-8. PMID: 14996721
8. TIS21/BTG2/PC3 is expressed through PKC-delta pathway and inhibits binding of cyclin B1-Cdc2 and its activity, independent of p53 expression.  |  Ryu, MS., et al. 2004. Exp Cell Res. 299: 159-70. PMID: 15302583
9. Expression of the NF-kappaB-responsive gene BTG2 is aberrantly regulated in breast cancer.  |  Kawakubo, H., et al. 2004. Oncogene. 23: 8310-9. PMID: 15378000
10. Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway.  |  Rouault, JP., et al. 1996. Nat Genet. 14: 482-6. PMID: 8944033

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BTG2 Antibody (1A5) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-BTG2 Antibody (1A5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BTG2 Antibody (1A5) Specifications

Alternate Product Name: BTG2

Product Clone Name: 1A5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 59-158

Epitope Target: BTG2

Epitope Species: human

Product Reactivity/Detection: BTG2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for BTG2 Antibody (1A5): N/A

The preferred BTG2 antibody is BTG2 Antibody (E-4): sc-518098.