Blk Antibody (G-8): sc-393960

Blk Antibody (G-8) is a mouse monoclonal IgG2b light chain antibody that detects Blk in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Blk, or B lymphocyte kinase, is a crucial protein that plays a significant role in B lymphocyte signaling pathways, which are essential for adaptive immune response. Blk (G-8) antibody targets proteins primarily located in B cell cytoplasm, where Blk regulates various cellular processes, including proliferation and differentiation. Anti-Blk antibody (G-8) enables detection of this vital protein for maintaining immune homeostasis, as Blk helps modulate B cell activation and survival. Dysregulation of Blk has been implicated in several hematological malignancies, highlighting Blk′s importance in both normal immune function and disease. Blk monoclonal antibody (G-8) provides a reliable tool for researchers studying B cell biology and underlying mechanisms of immune-related disorders, enabling a deeper understanding of how Blk contributes to immune responses and potential therapeutic targets.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Blk Antibody (G-8) References:

1. Structure and developmental regulation of the B-lymphoid tyrosine kinase gene blk.  |  Dymecki, SM., et al. 1992. J Biol Chem. 267: 4815-23. PMID: 1537861
2. Association of the FAM167A-BLK region with systemic sclerosis.  |  Ito, I., et al. 2010. Arthritis Rheum. 62: 890-5. PMID: 20131239
3. Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genes BANK1 and BLK.  |  Castillejo-López, C., et al. 2012. Ann Rheum Dis. 71: 136-42. PMID: 21978998
4. The autoimmunity-associated BLK haplotype exhibits cis-regulatory effects on mRNA and protein expression that are prominently observed in B cells early in development.  |  Simpfendorfer, KR., et al. 2012. Hum Mol Genet. 21: 3918-25. PMID: 22678060
5. The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells.  |  Zhang, H., et al. 2012. Nat Genet. 44: 861-71. PMID: 22797726
6. Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription.  |  Guthridge, JM., et al. 2014. Am J Hum Genet. 94: 586-98. PMID: 24702955
7. Dysfunctional BLK in common variable immunodeficiency perturbs B-cell proliferation and ability to elicit antigen-specific CD4+ T-cell help.  |  Compeer, EB., et al. 2015. Oncotarget. 6: 10759-71. PMID: 25926555
8. Interaction analysis between BLK rs13277113 polymorphism and BANK1 rs3733197 polymorphism, MMEL1/TNFRSF14 rs3890745 polymorphism in determining susceptibility to rheumatoid arthritis.  |  Huang, H., et al. 2017. Autoimmunity. 50: 403-408. PMID: 28925718
9. Evaluation of Evidence for Pathogenicity Demonstrates That BLK, KLF11, and PAX4 Should Not Be Included in Diagnostic Testing for MODY.  |  Laver, TW., et al. 2022. Diabetes. 71: 1128-1136. PMID: 35108381
10. Malignant transformation of early lymphoid progenitors in mice expressing an activated Blk tyrosine kinase.  |  Malek, SN., et al. 1998. Proc Natl Acad Sci U S A. 95: 7351-6. PMID: 9636152

The preferred Blk antibody is Blk Antibody (9D10D1): sc-65980.