Date published: 2026-3-7

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Blk Inhibitors

The class of Blk inhibitors encompasses a range of compounds that potentially modulate the activity of Blk indirectly through their action on various kinases and cell signaling pathways. These inhibitors, while not binding directly to Blk, can influence the kinase's functionality by altering the cellular environment or the signaling networks in which Blk participates. For example, tyrosine kinase inhibitors like Imatinib, Dasatinib, and Nilotinib, primarily known for their action on BCR-ABL and other kinases, can exert an influence on Blk due to their broad-spectrum kinase inhibition profile. By affecting the activity of related kinases, these compounds might indirectly modulate Blk's role in B-cell signaling and development. Furthermore, inhibitors targeting EGFR, such as Erlotinib, Lapatinib, and Gefitinib, might also impact Blk indirectly. As Blk is involved in signaling pathways that are interconnected with EGFR-mediated pathways, the inhibition of EGFR can result in alterations in the downstream signaling cascade, potentially affecting Blk activity. Additionally, multi-targeted inhibitors like Sorafenib and Sunitinib, which inhibit a range of kinases, present a potential for indirect modulation of Blk activity. The inhibition of key kinases in B-cell signaling pathways can influence Blk's function, given the kinase's role in these pathways. Compounds like Palbociclib, which inhibits CDKs, also contribute to this class by affecting cell cycle regulation, thereby indirectly influencing kinases like Blk involved in cell proliferation and signaling.

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

A 419259 trihydrochloride

1435934-25-0sc-361094
5 mg
$213.00
6
(1)

A 419259 trihydrochloride functions as a selective modulator of cellular signaling pathways, exhibiting unique interactions with specific receptors. Its chemical structure promotes effective hydrogen bonding, enhancing affinity for target sites. The compound's stability in aqueous environments allows for sustained activity, while its kinetic profile reveals a rapid engagement with molecular targets, leading to significant alterations in downstream signaling cascades. Additionally, its ionic nature contributes to enhanced solubility, facilitating effective cellular uptake.

Lck Inhibitor Inhibitor

213743-31-8sc-204052
1 mg
$362.00
5
(1)

Lck Inhibitor acts as a potent disruptor of protein-protein interactions, specifically targeting the Lck kinase domain. Its unique conformation allows for precise binding to the ATP-binding site, effectively blocking phosphorylation events. The compound exhibits a favorable reaction kinetics profile, characterized by a rapid onset of action and prolonged engagement with its target. Its hydrophilic characteristics enhance solubility, promoting efficient distribution within cellular compartments, thereby influencing various signaling networks.

Imatinib

152459-95-5sc-267106
sc-267106A
sc-267106B
10 mg
100 mg
1 g
$26.00
$119.00
$213.00
27
(1)

A tyrosine kinase inhibitor primarily targeting BCR-ABL, but can also affect other kinases and potentially influence Blk activity.

Dasatinib

302962-49-8sc-358114
sc-358114A
25 mg
1 g
$70.00
$145.00
51
(1)

Another broad-spectrum tyrosine kinase inhibitor, which could potentially impact Blk among other kinases.

Erlotinib, Free Base

183321-74-6sc-396113
sc-396113A
sc-396113B
sc-396113C
sc-396113D
500 mg
1 g
5 g
10 g
100 g
$87.00
$135.00
$293.00
$505.00
$3827.00
42
(0)

Primarily targets the epidermal growth factor receptor (EGFR) but may have off-target effects on other tyrosine kinases including Blk.

Sorafenib

284461-73-0sc-220125
sc-220125A
sc-220125B
5 mg
50 mg
500 mg
$57.00
$100.00
$250.00
129
(3)

Inhibits multiple kinases and might indirectly affect Blk activity through its broad-spectrum activity.

Sunitinib, Free Base

557795-19-4sc-396319
sc-396319A
500 mg
5 g
$153.00
$938.00
5
(0)

A multi-targeted tyrosine kinase inhibitor that could potentially have an effect on Blk.

Nilotinib

641571-10-0sc-202245
sc-202245A
10 mg
25 mg
$209.00
$413.00
9
(1)

A BCR-ABL inhibitor that may also affect other tyrosine kinases including Blk.

AP 24534

943319-70-8sc-362710
sc-362710A
10 mg
50 mg
$175.00
$983.00
2
(1)

A potent multi-kinase inhibitor that could potentially impact Blk activity.

Palbociclib

571190-30-2sc-507366
50 mg
$321.00
(0)

Inhibits cyclin-dependent kinases (CDKs) and might indirectly influence Blk through cell cycle regulation pathways.