BACE2 Antibody (F-12): sc-271286
- BACE2 Antibody (F-12) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 429-518 mapping near the C-terminus of BACE2 of human origin
- recommended for detection of BACE2 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for BACE2 Antibody (F-12) for WB applications. This reagent is now offered in a bundle with BACE2 Antibody (F-12) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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BACE2 Antibody (F-12) is a mouse monoclonal IgG1 antibody that detects BACE2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BACE2, or beta-site amyloid precursor protein cleaving enzyme 2, plays a crucial role in processing amyloid precursor protein (APP), contributing to the generation of amyloid beta peptides implicated in Alzheimer′s disease pathogenesis. BACE2 is primarily localized in the Golgi apparatus and endosomes, where BACE2 is involved in APP cleavage, thus influencing amyloid beta production. Proper localization of BACE2 ensures cleavage occurs in appropriate cellular compartments, regulating amyloid beta levels and potentially impacting neurodegenerative disease development. Anti-BACE2 antibody (F-12) serves as an invaluable tool for researchers studying Alzheimer′s disease mechanisms and amyloid beta′s role in neurodegeneration, providing insights into potential therapeutic targets and strategies.
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BACE2 Antibody (F-12) References:
- BACE2 expression increases in human neurodegenerative disease. | Holler, CJ., et al. 2012. Am J Pathol. 180: 337-50. PMID: 22074738
- BACE2 degradation mediated by the macroautophagy-lysosome pathway. | Liu, X., et al. 2013. Eur J Neurosci. 37: 1970-7. PMID: 23773066
- BACE2 distribution in major brain cell types and identification of novel substrates. | Voytyuk, I., et al. 2018. Life Sci Alliance. 1: e201800026. PMID: 30456346
- BACE2, a conditional β-secretase, contributes to Alzheimer's disease pathogenesis. | Wang, Z., et al. 2019. JCI Insight. 4: PMID: 30626751
- BACE2 degradation is mediated by both the proteasome and lysosome pathways. | Qiu, K., et al. 2020. BMC Mol Cell Biol. 21: 13. PMID: 32160867
- A Structure-Based Discovery Platform for BACE2 and the Development of Selective BACE Inhibitors. | Yen, YC., et al. 2021. ACS Chem Neurosci. 12: 581-588. PMID: 33544569
- m6A RNA hypermethylation-induced BACE2 boosts intracellular calcium release and accelerates tumorigenesis of ocular melanoma. | He, F., et al. 2021. Mol Ther. 29: 2121-2133. PMID: 33601055
- BACE2 suppression in mice aggravates the adverse metabolic consequences of an obesogenic diet. | Díaz-Catalán, D., et al. 2021. Mol Metab. 53: 101251. PMID: 34015524
- BACE2 variant identified from HSCR patient causes AD-like phenotypes in hPsc-derived brain organoids. | Luo, J., et al. 2022. Cell Death Discov. 8: 47. PMID: 35110536
- BACE2 deficiency impairs expression and function of endothelial nitric oxide synthase in brain endothelial cells. | He, T., et al. 2023. J Neurochem. 166: 928-942. PMID: 37547981
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BACE2 Antibody (F-12) | sc-271286 | 200 µg/ml | $316.00 | |||
BACE2 Antibody (F-12): m-IgGκ BP-HRP Bundle | sc-534917 | 200 µg Ab; 40 µg BP | $354.00 |