BAALC Antibody (H-12): sc-515606
- BAALC Antibody (H-12) is a mouse monoclonal IgG2b κ BAALC antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 39-56 within an internal region of BAALC of human origin
- BAALC Antibody (H-12) is recommended for detection of BAALC of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-BAALC Antibody (H-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for BAALC Antibody (H-12) for WB applications. These reagents are now offered in bundles with BAALC Antibody (H-12) (see ordering information below).
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BAALC Antibody (H-12) is a mouse monoclonal IgG2b kappa light chain antibody that detects BAALC protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BAALC (H-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BAALC protein, which stands for brain and acute leukemia, cytoplasmic, is a 180 amino acid protein expressed in hematopoietic and neural cells, localizing to both membrane and cytoplasm, and existing as multiple alternatively spliced isoforms. BAALC interacts with calcium/calmodulin-dependent protein kinase II alpha (CaMKIIα), which is crucial for synaptic function, particularly at postsynaptic lipid rafts, highlighting its importance in neuronal signaling and plasticity. BAALC may be overexpressed in acute myeloid leukemia (AML), suggesting a potential role in tumorigenesis and making BAALC a significant marker for studying this malignancy. BAALC gene is located on human chromosome 8, a region associated with various diseases and genetic disorders, including schizophrenia, bipolar disorder, and certain leukemias and lymphomas, underscoring BAALC relevance in both normal physiology and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
BAALC Antibody (H-12) References:
- BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia. | Tanner, SM., et al. 2001. Proc Natl Acad Sci U S A. 98: 13901-6. PMID: 11707601
- Baalc, a marker of mesoderm and muscle. | Satoskar, AA., et al. 2005. Gene Expr Patterns. 5: 463-73. PMID: 15749074
- Low ERG and BAALC expression identifies a new subgroup of adult acute T-lymphoblastic leukemia with a highly favorable outcome. | Baldus, CD., et al. 2007. J Clin Oncol. 25: 3739-45. PMID: 17646667
- High BAALC expression associates with other molecular prognostic markers, poor outcome, and a distinct gene-expression signature in cytogenetically normal patients younger than 60 years with acute myeloid leukemia: a Cancer and Leukemia Group B (CALGB) study. | Langer, C., et al. 2008. Blood. 111: 5371-9. PMID: 18378853
- Up-regulation of BAALC gene may be an important alteration in AML-M2 patients with t(8;21) translocation. | Qi, X., et al. 2008. J Cell Mol Med. 12: 2301-4. PMID: 18671757
- EVI1, BAALC and AME: prevalence of the secondary mutations in chronic and accelerated phases of chronic myeloid leukemia patients from eastern India. | Kuila, N., et al. 2009. Leuk Res. 33: 594-6. PMID: 18752846
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BAALC Antibody (H-12) | sc-515606 | 200 µg/ml | $316.00 | |||
BAALC Antibody (H-12): m-IgG Fc BP-HRP Bundle | sc-531436 | 200 µg Ab; 10 µg BP | $354.00 | |||
BAALC Antibody (H-12): m-IgGκ BP-HRP Bundle | sc-525125 | 200 µg Ab, 40 µg BP | $354.00 | |||
BAALC Antibody (H-12): m-IgG2b BP-HRP Bundle | sc-550286 | 200 µg Ab; 10 µg BP | $354.00 | |||
BAALC Antibody (H-12) AC | sc-515606 AC | 500 µg/ml, 25% agarose | $416.00 | |||
BAALC Antibody (H-12) HRP | sc-515606 HRP | 200 µg/ml | $316.00 | |||
BAALC Antibody (H-12) FITC | sc-515606 FITC | 200 µg/ml | $330.00 | |||
BAALC Antibody (H-12) PE | sc-515606 PE | 200 µg/ml | $343.00 | |||
BAALC Antibody (H-12) Alexa Fluor® 488 | sc-515606 AF488 | 200 µg/ml | $357.00 | |||
BAALC Antibody (H-12) Alexa Fluor® 546 | sc-515606 AF546 | 200 µg/ml | $357.00 | |||
BAALC Antibody (H-12) Alexa Fluor® 594 | sc-515606 AF594 | 200 µg/ml | $357.00 | |||
BAALC Antibody (H-12) Alexa Fluor® 647 | sc-515606 AF647 | 200 µg/ml | $357.00 | |||
BAALC Antibody (H-12) Alexa Fluor® 680 | sc-515606 AF680 | 200 µg/ml | $357.00 | |||
BAALC Antibody (H-12) Alexa Fluor® 790 | sc-515606 AF790 | 200 µg/ml | $357.00 | |||
BAALC (H-12) Neutralizing Peptide | sc-515606 P | 100 µg/0.5 ml | $68.00 |